CRISPR-assisted transposition: TnsC finds (and threads) the needle in the haystack.

Mol Cell

Laboratory of Bacteriology, The Rockefeller University, 1230 York Ave, New York, NY 10065, USA; Howard Hughes Medical Institute, The Rockefeller University, 1230 York Ave, New York, NY 10065, USA. Electronic address:

Published: November 2022

Hoffmann et al. (2022) demonstrate that RNA-guided transposons are remarkably sequence specific due to the action of a AAA+ ATPase, TnsC, that recruits the transposase to the correct target site.

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Source
http://dx.doi.org/10.1016/j.molcel.2022.10.014DOI Listing

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