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| http://dx.doi.org/10.1016/j.stem.2022.09.005 | DOI Listing |
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"The Brain is…": A Survey of the Brain's Many Definitions.
Neuroinformatics
January 2025
Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, 760 Westwood Plaza, Los Angeles, CA, 90024, USA.
A reader of the peer-reviewed neuroscience literature will often encounter expressions like the following: 'the brain is a dynamic system', 'the brain is a complex network', or 'the brain is a highly metabolic organ'. These expressions attempt to define the essential functions and properties of the mammalian or human brain in a simple phrase or sentence, sometimes using metaphors or analogies. We sought to survey the most common phrases of the form 'the brain is…' in the biomedical literature to provide insights into current conceptualizations of the brain.
View Article and Find Full Text PDFgoChem: A Composable Library for Multi-Scale Computational Chemistry Data Analysis.
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Departmento de Química, Facultad de Ciencias, Universidad de Tarapacá, Arica, Chile.
Data analysis is a major task for Computational Chemists. The diversity of modeling tools currently available in Computational Chemistry requires the development of flexible analysis tools that can adapt to different systems and output formats. As a contribution to this need, we report the implementation of goChem, a versatile open-source library for multiscale analysis of computational chemistry data.
View Article and Find Full Text PDFFrom Antipsychotic to Neuroprotective: Computational Repurposing of Fluspirilene as a Potential PDE5 Inhibitor for Alzheimer's Disease.
J Comput Chem
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Centre for Inflammation, Centenary Institute and University of Technology Sydney, Faculty of Science, School of Life Sciences, Sydney, New South Wales, Australia.
Phosphodiesterase 5 (PDE5) inhibitors have shown great potential in treating Alzheimer's disease by improving memory and cognitive function. In this study, we evaluated fluspirilene, a drug commonly used to treat schizophrenia, as a potential PDE5 inhibitor using computational methods. Molecular docking revealed that fluspirilene binds strongly to PDE5, supported by hydrophobic and aromatic interactions.
View Article and Find Full Text PDFSelf-Driving Microscopes: AI Meets Super-Resolution Microscopy.
Small Methods
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Dept. Chemical Engineering and Biotechnology, University of Cambridge, Cambridge, CB3 0AS, UK.
The integration of Machine Learning (ML) with super-resolution microscopy represents a transformative advancement in biomedical research. Recent advances in ML, particularly deep learning (DL), have significantly enhanced image processing tasks, such as denoising and reconstruction. This review explores the growing potential of automation in super-resolution microscopy, focusing on how DL can enable autonomous imaging tasks.
View Article and Find Full Text PDFAn Adaptive Spatio-Temporal Traffic Flow Prediction Using Self-Attention and Multi-Graph Networks.
Sensors (Basel)
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Department of Computer Science, King AbdulAziz University, Jeddah 21589, Saudi Arabia.
Traffic flow prediction is a pivotal element in Intelligent Transportation Systems (ITSs) that provides significant opportunities for real-world applications. Capturing complex and dynamic spatio-temporal patterns within traffic data remains a significant challenge for traffic flow prediction. Different approaches to effectively modeling complex spatio-temporal correlations within traffic data have been proposed.
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