Parkinson's disease is a nervous system abnormality marked by decreased dopamine levels in the brain. Parkinson's disease inhibits one's ability to move. Speech difficulty, changes in movement and handwriting, and other symptoms are common with Parkinson's disease. A collection of hand drawings is employed to predict Parkinson's disease. There are 102 spiral images in the hand drawing dataset. Due to the minimal size of the dataset, augmentation is utilized to increase it. After that, the augmented images are utilized to train several machine learning and deep learning models, as well as pre-trained networks like RESNET50, VGG16, AlexNet, and VGG19. The performance metrics of hybrid models of deep learning with machine learning and hybrid models of deep learning (for feature extraction) with deep learning (for classification) are then compared. It was observed that the hybrid model of RESNET-50 and SVM performed well with better performance measures compared to other Machine Learning, Deep Learning and Hybrid Models with an accuracy score of 98.45%, sensitivity score of 0.99 and specificity score of 0.98.
Download full-text PDF |
Source |
---|---|
http://dx.doi.org/10.1016/j.parkreldis.2022.10.020 | DOI Listing |
Eur J Neurosci
March 2025
Parkinson's Disease and Movement Disorders Clinic, Bangalore, India.
The release of synaptic vesicles (SVs) at the synaptic junction is a complex process involving various specialized proteins that work in unison. Among these, Bassoon has emerged as a significant protein, particularly noted for its association with various neurological and aging-related diseases. Due to its structural and functional roles, Bassoon has become a focus of recent research, especially in understanding its implications in neurodegenerative and psychiatric disorders.
View Article and Find Full Text PDFHandb Clin Neurol
March 2025
University School for Advanced Studies (IUSS-Pavia), Pavia, Italy; Dementia Research Center, IRCCS Mondino Foundation, Pavia, Italy. Electronic address:
Hemispheric asymmetry in pathologic involvement is frequently observed in neurodegenerative disorders (NDD) and is responsible for differences in cognitive and motor clinical manifestations in individual patients. While asymmetry is modest in typical Alzheimer disease (AD), atypical AD presentations with prominent language impairment [logopenic/phonologic variant of primary progressive aphasia (L/Phv-PPA)] are associated with prevalent involvement of the language-dominant hemisphere. Similarly, in the frontotemporal dementia-amyotrophic lateral sclerosis (FTD-ALS) spectrum, the semantic (Sv) and nonfluent/agrammatic (Nf/Av) variants of PPA are due to asymmetric pathology involving the language-dominant hemisphere.
View Article and Find Full Text PDFNeurotoxicology
March 2025
Laboratório Integrado de Biociências Translacionais, Instituto de Biodiversidade e Sustentabilidade - NUPEM, Universidade Federal do Rio de Janeiro - UFRJ, Macaé, Rio de Janeiro, 27965-045, Brazil; Pós-Graduação Multicêntrico em Ciências Fisiológicas, Instituto de Biodiversidade e Sustentabilidade - NUPEM, Universidade Federal do Rio de Janeiro - UFRJ, Macaé, Rio de Janeiro, 27965-045, Brazil. Electronic address:
Parkinson's disease (PD), a movement disorder caused by dopaminergic degeneration in the midbrain, has been induced in various organisms after injection of different neurotoxins, such as rotenone (ROT), which affect mitochondrial complex I. Due to the conserved characteristics of ascidians, these animals constitute an interesting model for comparative and genetic studies of neurodegenerative diseases. In this study, we investigated the effects of ROT on the ascidian nervous system, evaluating apoptosis, catecholaminergic enzymes, behavioral deficits, and mitochondrial dysfunction.
View Article and Find Full Text PDFComplement Ther Med
March 2025
Dr. Burhan Nalbantoğlu State Hospital, Neurology Department, Nicosia, Northern Cyprus TR-10 Mersin, Turkey. Electronic address:
Objectives: To examine the effect of integrated motor learning clinical pilates protocol we developed for patients with Parkinson's Disease (pwPD) on providing enduring motor skills in walking, balance, reaction time, cadence, and functional mobility at 3-months follow-up.
Design: A parallel-group, randomized controlled trial (RCT).
Setting: XXX Medical Center, XXX, and XXX Physiotherapy and Rehabilitation Center, Nicosia.
J Ethnopharmacol
March 2025
School of Pharmacy, Hubei University of Chinese Medicine, Wuhan, 430065, China; Key Laboratory of Chinese Medicinal Resource and Chinese Herbal Compound of the Ministry of Education, Hubei University of Chinese Medicine, Wuhan, 430065, China; Center of Traditional Chinese Medicine Modernization for Liver Diseases, Hubei University of Chinese Medicine, Wuhan, 430065, China; Hubei Shizhen Laboratory, Hubei University of Chinese Medicine, Wuhan, 430065, China. Electronic address:
Ethnopharmacological Relevance: Parkinson's disease (PD) is one of the most common neurodegenerative disorders, yet effective therapeutic options remain limited. Dendrobium huoshanense (DH), a medicinal and edible herb mainly distributed in Ta-pieh Mountains of Central China, has been used to treat disorders of consciousness and chronic nervous diseases in the local hospital for thousands of years. Erianin, a bioactive bibenzyl compound isolated from DH, has emerged as a potential neuroprotective agent due to its anti-inflammatory and antioxidant properties.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!