Porous Se@SiO nanoparticles improve oxidative injury to promote muscle regeneration via modulating mitochondria.

Acute skeletal muscle injuries are common among physical or sports traumas. The excessive oxidative stress at the site of injury impairs muscle regeneration. The authors have recently developed porous Se@SiO nanoparticles (NPs) with antioxidant properties. The protective effects were evaluated by cell proliferation, myogenic differentiation and mitochondrial activity. Then, the therapeutic effect was investigated in a cardiotoxin-induced muscle injury rat model. Porous Se@SiO NPs significantly protected the morphological and functional stability of mitochondria, thus protecting satellite cells from HO-induced damage to cell proliferation and myogenic differentiation. In the rat model, intervention with porous Se@SiO NPs promoted muscle regeneration. This study reveals the application potential of porous Se@SiO NPs in skeletal muscle diseases related to mitochondrial dysfunction.