Triterpenoids from and their anti-inflammatory and radical scavenging activity.

J Asian Nat Prod Res

Department of Cardiovascular Surgery, General Hospital of Northern Theater Command, Shenyang 110016, China.

Published: November 2022

A phytochemical investigation on 90% methanol extract from the leaves of led to the isolation of three new triterpenoids, jugsigiloids A-C (-). Structural elucidation of all the compounds were performed by spectral methods such as 1 D and 2 D (H-H COSY, HMQC, and HMBC) NMR spectroscopy, in addition to high resolution mass spectrometry. The isolated components were evaluated for anti-inflammatory activities against COX-1 and COX-2 and radical scavenging potential using DPPH test. As a result, triterpenoid exhibited selective inhibition on COX-2 (93.2%) at the concentration of 100 μM and significant DPPH scavenging activity (IC = 41.6 μM) comparable with positive control Trolox (IC = 42.8 μM).

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http://dx.doi.org/10.1080/10286020.2022.2137023DOI Listing

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