AI Article Synopsis
- Overlap syndrome happens when someone has two autoimmune liver diseases at the same time: autoimmune hepatitis and primary biliary cirrhosis.
- Membranous nephropathy is a kidney problem that usually occurs in people who don’t have diabetes, and it's very rare for it to happen alongside overlap syndrome.
- A patient was treated with a medicine called azathioprine, and it helped reduce their protein levels in urine and improve their liver function over 21 months.
Article Abstract
Overlap syndrome is the combination of autoimmune liver diseases, and this term usually describes the coexistence of autoimmune hepatitis (AIH) and primary biliary cirrhosis (PBC) in the same patient. Membranous nephropathy (MN) is the most common pattern of idiopathic nephrotic syndrome in patients without diabetes. The coexistence of PBC-AIH overlap syndrome and MN is very rare. Herein, the patient we describe exhibited large amounts of proteinuria and hepatic dysfunction nearly at the same time. We administered azathioprine to our patient. Fortunately, the patient demonstrated a good response to azathioprine, including a partial reduction in proteinuria from ~ 12.5 g/D to 2.62 g/D after 21 months of observation and the improvement of liver function. Our findings suggest that azathioprine may be a suitable treatment option for patients presenting with coexisting PBC-AIH overlap syndrome and MN.
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