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Variabilities of salivary human herpesvirus 6, 7, and secretory immunoglobulin A levels from pre- to post-competition periods in baseball players.
J Sports Med Phys Fitness
December 2024
Institute of Health and Sport Sciences, University of Tsukuba, Tsukuba, Japan -
Background: Persistent physical fatigue (PPhF) accompanying daily intensive training often results in underperformance. While salivary secretory immunoglobulin A (SIgA) has been traditionally used as an immunological marker, salivary human herpesvirus 6 and/or 7 (HHV-6/7) have recently been presented as "microbiological" markers of PPhF. This study aimed to examine the monthly variabilities of salivary HHV-6/7 levels and the difference with SIgA along the training periodization.
View Article and Find Full Text PDFComparative Efficacy of Different Pharmacological Treatments for Pityriasis Rosea: A Network Meta-Analysis.
J Clin Med
November 2024
Casa di Cura Villa Montallegro, 16100 Genoa, Italy.
Article Synopsis
- Pityriasis rosea (PR) is a skin condition that usually gets better on its own, often linked to reactivated human herpesviruses, causing mild rashes and itchiness.
- Traditional treatment focuses on reassuring patients to rest, but severe cases may require medication, prompting a study comparing various treatments.
- The analysis found that oral steroids and a combo with antihistamines were effective for itch relief, while acyclovir was the most effective for improving rash symptoms, making it the best option for more serious PR cases.
Human Herpesvirus-6B Infection and Alterations of Gut Microbiome in Patients with Fibromyalgia: A Pilot Study.
Biomolecules
October 2024
The Institute of Microbiology and Virology of the Riga Stradiņš University Science Hub, LV-1067 Riga, Latvia.
Article Synopsis
- * The study included 17 FM patients and 24 healthy individuals, aiming to identify potential biomarkers, detecting human herpesvirus (HHV)-6A and B in patient samples, and measuring related antibodies and cytokine levels.
- * Findings indicated higher detection of HHV-6B in FM patients, particularly those with a BMI of 30 or more, along with significant differences in gut microbiome diversity between FM patients and healthy controls.
Advances and prospect in herpesviruses infections after haematopoietic cell transplantation: closer to the finish line?
Clin Microbiol Infect
January 2025
Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Article Synopsis
- Herpesviruses are common complications after allogeneic hematopoietic cell transplantation (HCT), but recent advancements have improved their prevention and treatment over the past decade.
- Key developments include the introduction of letermovir and maribavir for cytomegalovirus (CMV) infections, the recombinant zoster vaccine for varicella zoster virus, and ongoing research into treatments for herpes simplex virus and Epstein-Barr virus.
- Despite these advances, challenges remain, particularly with Human Herpesvirus-6, and future strategies may involve new antivirals and enhanced immune therapies to further improve management of these infections.
HHV6-Associated Hydrocephalus in a Pediatric Hematopoietic Stem Cell Transplant Recipient: An Unusual Presentation.
J Pediatr Hematol Oncol
August 2024
Department of Pediatrics, College of Medicine and Health Sciences, United Arab Emirates University, Al-Ain.
Human herpesvirus 6 (HHV-6) is a widely spread DNA virus that is ubiquitous and persistent with primary infection occurring in early childhood, with reactivation of the infection a common phenomenon in severely immunocompromised hosts, including hematopoietic stem cell transplant (HSCT) patients, influencing morbidity and mortality. A wide spectrum of clinical presentations is reported in the literature with HHV-6 reactivation including post-transplant limbic encephalitis (PALE). We report the unusual case of a 6-year-old female 107 days postallogenic HSCT due to transfusion dependent beta thalassemia major who developed acute cerebellitis with secondary supratentorial hydrocephalus that required invasive surgical intervention.
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