Alzheimer's disease (AD) is a neurodegenerative disease caused by neurons damage in the brain, and it poses a serious threat to human life and health. No efficient treatment is available, but early diagnosis, discovery, and intervention are still crucial, effective strategies. In this study, an electrochemical sensing platform based on a superwettable microdroplet array was developed to detect multiple AD biomarkers containing Aβ40, Aβ42, T-tau, and P-tau181 of blood. The platform integrated a superwettable substrate based on nanoAu-modified vertical graphene (VG@Au) into a working electrode, which was mainly used for droplet sample anchoring and electrochemical signal generation. In addition, an electrochemical micro-workstation was used for signals conditioning. This superwettable electrochemical sensing platform showed high sensitivity and a low detection limit due to its excellent characteristics such as large specific surface, remarkable electrical conductivity, and good biocompatibility. The detection limit for Aβ40, Aβ42, T-tau, and P-tau181 were 0.064, 0.012, 0.039, and 0.041 pg/ml, respectively. This study provides a promising method for the early diagnosis of AD.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9622762PMC
http://dx.doi.org/10.3389/fbioe.2022.1029428DOI Listing

Publication Analysis

Top Keywords

based superwettable
8
superwettable microdroplet
8
microdroplet array
8
alzheimer's disease
8
early diagnosis
8
electrochemical sensing
8
sensing platform
8
aβ40 aβ42
8
aβ42 t-tau
8
t-tau p-tau181
8

Similar Publications

Covalent organic frameworks hybridized polymeric high internal phase emulsions with amphiphilicity for extraction of trace bisamide insecticides in food samples.

Mikrochim Acta

December 2024

Guangxi Colleges and Universities Key Laboratory of Food Safety and Detection, College of Chemistry and Bioengineering, Guilin University of Technology, Guilin, 541004, Guangxi, China.

Polymeric high internal phase emulsions decorated with covalent organic frameworks (polyHIPEs-COFs) were synthesized and used as the sorbent for cyantraniliprole and chlorantraniliprole. Pickering high internal phase emulsions stabilized by covalent organic frameworks solid particles and liquid surfactants (Span80 and polyvinylpyrrolidone) endow the composites with open-cell structures and superwettability. The amphiphilicity and open-cell structures enable rapid adsorption and desorption for cyantraniliprole and chlorantraniliprole, and the solid-phase extraction process can be completed in 5 min.

View Article and Find Full Text PDF

Preparation, characterization, and applications of kaolin/kaolin-based composite membranes in oily wastewater treatment: Recent developments, challenges, and opportunities.

J Environ Manage

November 2024

Department of Civil and Environmental Engineering, Khalifa University of Science and Technology, Abu Dhabi, United Arab Emirates; School of Chemical and Environmental Engineering, Technical University of Crete, Chania, Greece. Electronic address:

Rapid industrialization and the accompanying generation of significant amounts of oily wastewater pose major environmental challenges, which necessitate efficient treatment technologies. Kaolin-based membranes have emerged as a promising option due to their availability, affordability, and effective filtration performance. This review comprehensively analyzes the potential of kaolin for the treatment of oily wastewater.

View Article and Find Full Text PDF
Article Synopsis
  • - Stretchable transparent electrodes (STEs) made from silver nanowires and PDMS are key materials for flexible electronics, but current manufacturing methods are inefficient for large-scale production.
  • - This research introduces a new approach using a gradient PDMS substrate with adjustable properties, improving the performance of STEs in terms of optoelectrical characteristics, stretchability, and stability.
  • - The developed STEs are versatile, with potential applications in electro-heating and electroluminescent devices, and offer a simpler, more effective fabrication method compared to traditional techniques.
View Article and Find Full Text PDF

Utilizing superhydrophobic micro/nanostructures to enhance condensation heat transfer (CHT) of copper surfaces has attracted intensive interest in recent years due to its significance in multiple industrial fields including nuclear power generation, thermal management, water harvesting, and desalination. However, superhydrophobic surfaces have instability risk caused by microcavity defect-induced vapor penetration and/or hydrophobic chemistry destruction. Here, we report a superwetting copper hierarchical microgroove/nanocone (MGNC) structure strategy that can realize high-efficiency CHT over a whole range of surface subcooling.

View Article and Find Full Text PDF

Achieving Super-Metallophobicity on Silicon-based Ceramics at High Temperature.

Adv Mater

October 2024

CAS Key Laboratory of Bio-inspired Materials and Interfacial Science, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing, 100190, China.

As a critical concept in physical chemistry, superwettability is widely concerned in both fundamental science and practical engineering in past few decades. Despite this, investigation on high temperature superwettability is still a void, which is significant both in scientific and industrial fields. Herein, a ceramic with specific high temperature non-wetting property, SiNO is proposed.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!