Cytokine Release Syndrome and Sepsis: Analogous Clinical Syndromes with Distinct Causes and Challenges in Management.

Infect Dis Clin North Am

Internal Medicine Services, National Institutes of Health, Room 2-2734, Bethesda, MD 20892-1662, USA. Electronic address:

Published: December 2022

Both cytokine release syndrome (CRS) and sepsis are clinical syndromes rather than distinct diseases and share considerable overlap. It can often be challenging to distinguish between the two, but it is important given the availability of targeted treatment options. In addition, several other clinical syndromes overlap with CRS and sepsis, further making it difficult to differentiate them. This has particularly been highlighted in the recent coronavirus disease-2019 pandemic. As we start to understand the differences in the inflammatory markers and presentations in these syndromes, hopefully we will be able to enhance treatment and improve outcomes.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9641544PMC
http://dx.doi.org/10.1016/j.idc.2022.07.001DOI Listing

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