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| http://dx.doi.org/10.1016/j.jcmgh.2022.10.003 | DOI Listing |
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The tumor microenvironment (TME) is a complex, highly structured, and dynamic ecosystem that plays a pivotal role in the progression of both primary and metastatic tumors. Precise assessment of the dynamic spatiotemporal features of the TME is crucial for understanding cancer evolution and designing effective therapeutic strategies. Cancer is increasingly recognized as a systemic disease, influenced not only by the TME, but also by a multitude of systemic factors, including whole-body metabolism, gut microbiome, endocrine signaling, and circadian rhythm.
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Aldose reductase inhibitors: 2013-present.
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a Dipartimento di Farmacia , Università di Pisa, Pisa , Italy.
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