Background: Condyle-spanning plate-screw constructs have shown potential to lower the risks of femoral refractures after the healing of a primary Vancouver type B1 periprosthetic femoral fracture. Limited information exists to show how osteoporosis (a risk factor for periprosthetic femoral fractures) may affect the plate fixation during activities of daily living.
Methods: Using total hip arthroplasty and plate-implanted finite element models of three osteoporotic femurs, this study simulated physiological loads of three activities of daily living, as well as osteoporosis associated muscle weakening, and compared the calculated stress/strain, load transfer and local stiffness with experimentally validated models of three healthy femurs. Two plating systems and two construct lengths (a diaphyseal construct and a condyle-spanning construct) were modeled.
Findings: Osteoporotic femurs showed higher bone strain (21.9%) and higher peak plate stress (144.3%) as compared with healthy femurs. Compared with shorter diaphyseal constructs, condyle-spanning constructs of two plating systems reduced bone strains in both healthy and osteoporotic femurs (both applying 'the normal' and 'the weakened muscle forces') around the most distal diaphyseal screw and in the distal metaphysis, both locations where secondary fractures are typically reported. The lowered resultant compressive force and the increased local compressive stiffness in the distal diaphysis and metaphysis may be associated with strain reductions via condyle-spanning constructs.
Interpretation: Strain reductions in condyle-spanning constructs agreed with the clinically reported lowered risks of femoral refractures in the distal diaphysis and metaphysis. Multiple condylar screws may mitigate the concentrated strains in the lateral condyle, especially in osteoporotic femurs.
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http://dx.doi.org/10.1016/j.clinbiomech.2022.105801 | DOI Listing |
Brain Spine
March 2024
Consultant Orthopaedic Surgeon, San Carlo Borromeo Hospital, Via Pio II 3, Milano, Italy.
Introduction: Bisphosphonates are commonly used to prevent osteoporotic fractures. Many randomized controlled trials have proved the efficacy of bisphosphonates, showing their ability to increase bone mineral density and decrease the risk of hip and vertebral fractures. Atypical, bisphosphonate-related fractures concerning the femur have been widely described and a list of primary and secondary clinical and radiographic criteria are used in order to achieve diagnosis.
View Article and Find Full Text PDFUlus Travma Acil Cerrahi Derg
January 2025
Department of Biochemistry, Gulhane Faculty of Pharmacy, University of Health Sciences, Ankara-Türkiye.
Background: Osteoporosis is characteristically defined as a decrease in bone density and mass, accompanied by the deterioration of bone structure, which increases bone fragility and the risk of fractures. Osteoporosis frequently develops with age. In high-risk populations, oxidative damage is a common pathological condition.
View Article and Find Full Text PDFJ Nutr Sci Vitaminol (Tokyo)
January 2025
R&D Headquarters, Kracie, Ltd.
The Forsythia has been used in herbal medicine, and the leaf is also expected to contain various putative bioactive substances. In this study, we investigated the effects of Forsythia viridissima leaf extract (FLE) on bone metabolism. The anti-osteoporotic effect of FLE was determined in male rats fed a low-calcium diet.
View Article and Find Full Text PDFTunis Med
December 2024
Orthopaedic Department, Fattouma Bourguiba Hospital, Monastir Faculty of Medicine, University of Monastir, Tunisia.
Objectives: To evaluate survival after osteoporotic fractures of the upper femur and determine its associated factors.
Methods: Cross-sectional study of patients hospitalized for fractures of the upper end of the femur during 2020 at Monastir University Hospital. Outcome was determined up to 2 years.
PLoS One
December 2024
Department of Orthopaedics, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China.
Background: Recently researches have reported that miRNA and its target genes are associated with osteoporosis. MiRNA and mRNA might be potential diagnostic markers for osteoporosis.
Purposes: The aim of this study is to explore the potential miRNA and mRNA markers by bioinformatics method and clinical analysis.
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