AI Article Synopsis
- The study investigates the potential health risks of enrofloxacin (ENR) abuse in aquaculture, highlighting the need for better monitoring of its metabolites beyond ciprofloxacin (CIP).
- It employs an advanced analysis technique to successfully identify a new ENR metabolite, deethylene-ENR, alongside CIP in real fish samples.
- The research establishes a reliable method for measuring ENR, CIP, and deethylene-ENR in aquatic products, revealing that deethylene-ENR is present in a significant number of fish samples, raising concerns about its safety.
Article Abstract
The abuse of enrofloxacin (ENR) in aquaculture and the lack of monitoring of other metabolites except ciprofloxacin (CIP) may lead to unknown harmful effects on human health. In this study, ENR metabolites were screened in real fish samples based on ultrahigh-performance liquid chromatography coupled with Q-Orbitrap mass spectrometry combined with Compound Discoverer software, and another metabolite deethylene-ENR besides CIP was detected and identified for the first time. Correspondingly, a method for the determination of ENR and CIP and the semi-quantitative analysis of deethylene-ENR in aquatic products was established. Method validation illustrated that excellent linearity and satisfactory recoveries of analytes were obtained. Limits of detection of ENR and CIP were both 0.1 μg kg, and their limits of quantification both 1 μg kg. CIP and deethylene-ENR were detected in 12 of 14 ENR-positive fish samples, so deethylene-ENR should be of concern as a possible risk candidate in aquatic products.
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| http://dx.doi.org/10.1016/j.foodchem.2022.134757 | DOI Listing |
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