A Mn catalyst featuring redox-active tridentate phenalenyl (PLY) ligand has been used for catalytic N-formylation of secondary amides and lactams under 1 atm CO as a C source at room temperature for the first time. The protocol is applicable to a wide range of secondary amides including heterocycles, bio-active cinnamide derivatives and the diversification of therapeutic molecules. In-depth mechanistic investigations based on experimental outcomes and DFT calculations suggested an unconventional metal-ligand cooperation, where a ligand-centred radical plays a crucial role in initiating the reaction process.
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