AI Article Synopsis
- This study tested a new mouth rinse containing Cetylpyridinium chloride and essential oils to see if it helps prevent plaque build-up in patients with gingivitis after dental cleaning.
- The trial involved 118 participants who used either the test mouth rinse or a control rinse for 12 weeks, with results showing lower plaque scores in the treatment group.
- Although both groups improved in gingivitis, the rinse's long-term use may be affected by side effects, and a notable percentage of participants dropped out of the study.
Article Abstract
Background: This single-center, randomized controlled trial aimed to determine the effectiveness of a novel, biofilm-disrupting, mouth rinse that combines Cetylpyridinium chloride (CPC) and essential oils in preventing re-accumulation of supragingival plaque and supragingival microbiome in patients with gingivitis after dental prophylaxis.
Methods: One hundred eighteen participants were randomly assigned in a 1:1 ratio to receive twice-daily test mouth rinse (59) or carrier rinse control (59) for 12 weeks after dental prophylaxis.
Results: In a per-protocol analysis that included patients who completed the intervention, the treatment group (39) had significantly lower supragingival plaque scores at 6 and 12 weeks compared to the control group (41; p = 0.022). Both groups showed similar improvement in gingivitis score, but neither group had improvement in bleeding score or probing depth. Thirty-eight (29%) patients did not complete the study due to loss of follow-up (17) or early discontinuation of the assigned intervention (21). Microbiome sequencing showed that the treatment rinse significantly depleted abundant and prevalent members of the supragingival plaque microbiome consortium.
Conclusions: Among patients with gingivitis, the novel mouth rinse significantly reduced re-accumulation of supragingival plaque following dental prophylaxis by depleting supragingival plaque microbiome. However, long-term adherence to the rinse may be limited by adverse effects ( ClinicalTrials.gov number, NCT03154021).
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9632080 | PMC |
| http://dx.doi.org/10.1186/s12903-022-02518-2 | DOI Listing |
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- An innovative toothbrush was created with a rotatable shank and a flexible design to improve access to all surfaces of the mouth, aimed at reducing plaque and improving gingival health.
- A randomized controlled trial compared this rotatable shank toothbrush with traditional flexible and straight handle toothbrushes to see which was more effective for plaque control and gingival health outcomes.
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