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Predicting peritumoral glioblastoma infiltration and subsequent recurrence using deep-learning-based analysis of multi-parametric magnetic resonance imaging.
J Med Imaging (Bellingham)
September 2024
University of Pennsylvania, Perelman School of Medicine, Department of Radiology, Philadelphia, Pennsylvania, United States.
Article Synopsis
- Glioblastoma (GBM) is an aggressive brain tumor that often infiltrates beyond its visible boundaries, making treatment challenging with standard surgical and chemoradiotherapy approaches.
- A new method was developed that combines expert insights and data augmentation to improve predictions of tumor infiltration using preoperative magnetic resonance imaging (mpMRI) scans from 229 patients.
- The model was validated through cross-institutional tests, showing varying effectiveness in predicting tumor recurrence, with odds ratios indicating strong potential for guiding targeted treatment strategies.
Density of tertiary lymphoid structures and their correlation with prognosis in non-small cell lung cancer.
Front Immunol
August 2024
Department of Health Examination Center, The Second Affiliated Hospital of Dalian Medical University, Dalian, China.
Background: Tertiary lymphoid structures (TLS), ordered structure of tumor-infiltrating immune cells in tumor immune microenvironment (TIME), play an important role in the development and anti-tumor immunity of various cancers, including liver, colon, and gastric cancers. Previous studies have demonstrated that the presence of TLS in intra-tumoral (IT), invasive margin (IM), and peri-tumoral (PT) regions of the tumors at various maturity statuses. However, the density of TLS in different regions of non-small cell lung cancer (NSCLC) has not been extensively studied.
View Article and Find Full Text PDFDiffusion tensor imaging in detecting gliomas sub-regions of infiltration, local and remote recurrences: a systematic review.
Neurosurg Rev
July 2024
Neurosurgery Unit, Department of Neurosciences, Catholic University School of Medicine, Rome, Italy.
Given that glioma cells tend to infiltrate and migrate along WM tracts, leading to demyelination and axonal injuries, Diffusion Tensor Imaging (DTI) emerged as a promising tool for identifying major "high-risk areas" of recurrence within the peritumoral brain zone (PBZ) or at a distance throughout the adjacents white matter tracts. Of our systematic review is to answer the following research question: In patients with brain tumor, is DTI able to recognizes within the peri-tumoral brain zone (PBZ) areas more prone to local (near the surgical cavity) or remote recurrence compared to the conventional imaging techniques?. We conducted a comprehensive literature search to identify relevant studies in line with the PRISMA-P (Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols) guidelines.
View Article and Find Full Text PDF[Surgical and pathological consequences of preoperative immunotherapy in onco-urology].
Bull Cancer
September 2024
Service d'urologie, CHU d'Angers, université d'Angers, Angers, France.
Introduction: Patients treated with immunotherapy might need surgical procedures in addition to the medical treatment. The main indications are cytoreductive nephrectomy, cystectomy (as part of clinical trials) and metastasis removal in some oligometastatic patients. This study aims to assess the feasibility of surgery for patients treated by immunotherapy and describes the histological modifications found in the pathological analysis.
View Article and Find Full Text PDFImmunochemistry-based quantification of tumor-infiltrating lymphocytes and immunoscore as prognostic biomarkers in bladder cancer.
J Egypt Natl Canc Inst
March 2024
Department of Urology, Hopital des forces de sécurité intérieure de la Marsa, Tunis, Tunisia.
Background: Tumor-infiltrating lymphocytes (TILs) and the derived immunoscore (IS) have gained considerable attention over the last decade as prognostic markers in many solid cancers. However, in bladder cancer (BC), their prognostic value is not clearly established.
Methods: The present study aimed to quantify the TILs rates in BC, assess the derived immunoscore, and investigate their prognostic value.
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