15-Prostaglandin dehydrogenase (15-PGDH) regulates the concentration of prostaglandin E2 . Inhibitors of 15-PGDH elevate PGE2 levels and promote tissue repair and regeneration. Here, we describe a novel class of quinoxaline amides that show potent inhibition of 15-PGDH, good oral bioavailability, and protective activity in mouse models of ulcerative colitis and recovery from bone marrow transplantation.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9885488 | PMC |
| http://dx.doi.org/10.1021/acs.jmedchem.2c01299 | DOI Listing |
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