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Monophasic synovial sarcoma arising from the rectum presenting as intractable anal pain.
BMJ Case Rep
January 2025
Department of Laboratories, Philippine General Hospital, Manila, Philippines.
Synovial sarcoma is a rare malignant mesenchymal tumour typically found in the extremities, but it can also develop in the gastrointestinal tract, with the upper rectum being the most common site. We describe a case of a man in his 60s diagnosed with monophasic synovial sarcoma in the lower rectum, presenting with severe, intractable anal pain.
View Article and Find Full Text PDFIntriguing tumor, synovial sarcoma: Hard to diagnose, harder to treat.
Orthop Traumatol Surg Res
January 2025
Ankara University Medical Faculty, İbni Sina Hospital, Department of Orthopedics and Traumatology, Talatpasa Boulevard no:82, 06630 Ankara, Turkey.
Background: Synovial sarcoma (SS) is classified as an aggressive high-grade soft tissue sarcoma that predominantly affects the extremities. Despite its prevalence in the extremities (up to 80%), diagnostic and treatment challenges persist. This study aims to address these challenges by providing a comprehensive analysis of SS in extremities, focusing on diagnostic accuracy and treatment outcomes.
View Article and Find Full Text PDFAn unusual presentation of primary synovial sarcoma of the ethmoid sinus in a 54-year-old woman: A case report and literature review.
Int J Surg Case Rep
January 2025
Department of Pathology, An-Najah National University Hospital, Nablus, Palestine.
Introduction And Importance: Synovial sarcoma is a malignant soft tissue tumor primarily affects the extremities. Its presence in the paranasal sinuses, especially within the ethmoid sinus, is exceedingly rare.
Case Presentation: We report a case of monophasic synovial sarcoma of the ethmoid sinus in a 54-year-old woman, who presented with 3 months history of left eye pain and bulging.
Immunological differences between monophasic and biphasic synovial sarcoma with implications for immunotherapy.
Cancer Immunol Immunother
December 2024
Department of Hematology, Leiden University Medical Center, Leiden, The Netherlands.
Article Synopsis
- Synovial sarcoma is a type of aggressive soft-tissue cancer with limited response to current immunotherapies, highlighting the need for better understanding of the immune cells in its tumor microenvironment.
- Researchers studied 41 patients to analyze the relationship between immune cell types, tumor subtype (biphasic vs. monophasic), disease progression, and response to treatments like chemotherapy.
- Findings indicated that biphasic synovial sarcomas had a higher presence of immune cells, particularly T cells, which correlated with better patient survival, suggesting they may respond more favorably to immunotherapies.
Synovial sarcoma of the larynx, a rare and unusual entity. Case report.
Int J Surg Case Rep
January 2025
Pathology Department, National Medical Center "20 de Noviembre", Mexico City, MX. Mexico.
Introduction And Importance: Synovial sarcoma (SS) is a high-grade malignancy, accounting for 2.5-3.5 % of all primary H&N sarcomas and 0.
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