AI Article Synopsis
- The study focused on how the transcription factor Oct4 is expressed in chromaffin cells during the growth of adrenal glands in rats after birth.
- Researchers found that as the developmental stage progressed, the number of Oct4-positive chromaffin cells rose while the overall cell division decreased.
- All Oct4-expressing cells were identified as mature chromaffin cells, indicating they play a role in the adrenal medulla's potential for regeneration and recovery after growth has finished.
Article Abstract
We analyzed the expression of the transcription factor Oct4 in the chromaffin cells during the postnatal development of the adrenal glands in rats. Single Oct4-chromaffin cells with nuclear localization of the protein were found in the medulla, and their number increased in parallel with a decrease in the proliferative activity of cells. In postnatal development, 100% of chromaffin cells demonstrated high expression of tyrosine hydroxylase, which attested to their differentiation and functional activity. It was found that all Oct4 cells were differentiated chromaffin cells. An increase in the pool of Oct4-expressing cells after the completion of organ growth suggests the formation of a potential source for the physiological and reparative regeneration of the adrenal medulla.
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| http://dx.doi.org/10.1007/s10517-022-05631-y | DOI Listing |
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