Introduction: Inadequate oxygen availability may lead to impairment of neurocognitive functions. The aim of the present study was to investigate the effect of acute high-altitude exposure on the cerebral hemodynamic response and working memory.
Methods: The same subjects performed working memory exercises with forward and backward digit span tasks both under normal oxygen conditions and in large simulated hypobaric hypoxia chambers, and a series of physiological parameters were evaluated. Functional near-infrared spectroscopy was used to measure cerebral blood flow changes in the dorsolateral prefrontal cortex (DLPFC) during the tasks.
Results: Compared with normoxic conditions, under hypoxic conditions, the heart rate and blood pressure increased, blood oxygen saturation decreased significantly, and the forward task had similar accuracy and response time, while the backward task had lower accuracy and longer response time. Neuroimaging analysis showed increased activation in the DLPFC during the forward task and deactivation during the backward task under hypobaric hypoxia conditions.
Conclusion: Acute high-altitude exposure leads to physiological adaptations. The abnormal hemodynamic responses of the DLPFC to hypoxia at low pressure reveal the disruption of neurocognitive function by acute high-altitude exposure, which compromises complex cognitive functions, and provides a promising application for functional near infrared spectroscopy in the exploration of neural mechanisms in the brain during high-altitude exposure.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9759148 | PMC |
| http://dx.doi.org/10.1002/brb3.2776 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Longitudinal assessment of retinal and visual pathway electrophysiology and structure after high altitude exposure.
Graefes Arch Clin Exp Ophthalmol
January 2025
Institute of Brain Diseases and Cognition, School of Medicine, Xiamen University, Xiamen, 361102, Fujian, China.
High altitude (HA) exposure induces impairments in visual function. This study was designed to dynamically observe visual function after returning to lowland and elucidate the underlying mechanism by examining the structure and function of retina and visual pathway. Twenty-three subjects were recruited before (Test 1), and one week (Test 2) and three months (Test 3) after their return from HA (4300 m) where they resided for 30 days.
View Article and Find Full Text PDFEffect of condensed heat acclimation on thermophysiological adaptations, hypoxic cross-tolerance, exercise performance and de-acclimation.
J Appl Physiol (1985)
January 2025
Extreme Environments Laboratory, School of Psychology, Sport and Health Sciences, University of Portsmouth, UK.
Short duration heat acclimation (HA) (≤5 daily heat exposures) elicits incomplete adaptation compared to longer interventions, possibly due to the lower accumulated thermal 'dose'. It is unknown if matching thermal 'dose' over a shorter timescale elicits comparable adaptation to a longer intervention. Using a parallel-groups design, we compared: i) 'condensed' HA (CHA; =17 males) consisting of 4×75 min∙day heat exposures (target rectal temperature ()=38.
View Article and Find Full Text PDFDeep learning reveals diverging effects of altitude on aging.
Geroscience
January 2025
Center for Healthy Aging, Department of Cellular and Molecular Medicine, University of Copenhagen, Copenhagen, Denmark.
Aging is influenced by a complex interplay of multifarious factors, including an individual's genetics, environment, and lifestyle. Notably, high altitude may impact aging and age-related diseases through exposures such as hypoxia and ultraviolet (UV) radiation. To investigate this, we mined risk exposure data (summary exposure value), disease burden data (disability-adjusted life years (DALYs)), and death rates and life expectancy from the Global Health Data Exchange (GHDx) and National Data Management Center for Health of Ethiopia for each subnational region of Ethiopia, a country with considerable differences in the living altitude.
View Article and Find Full Text PDFChoroidal thickening and retinal dopamine increase in mice at high altitude.
Exp Eye Res
January 2025
Department of Ophthalmology, The Second Hospital &Clinical Medical School, Lanzhou University, Gansu, 730000, China. Electronic address:
The mechanisms underlying the low incidence of myopia at high altitudes remain unclear. Choroidal thickness and the dopaminergic system have been shown to be closely associated with myopia development. This study aimed to investigate the effects of high altitude exposure on choroidal thickness and the dopaminergic system.
View Article and Find Full Text PDFRefractive Changes and Corneal Thickness in Healthy Mountaineers at High Altitude: The Korzhenevskoi Experience (7105 m).
Cornea
January 2025
Department of Ophthalmology, Rothschild Foundation, Paris, France; and.
Purpose: The purpose of this study was to investigate the effect of hypoxia and hypobaric conditions on refraction and central corneal thickness on healthy corneas during an ascent without oxygen supplementation above 7000 m (23 000 ft).
Methods: Twelve multinational mountaineers were included in a prospective observational cohort study during an expedition to the Korzhenevskoi Peak (7105 m). The two patients excluded from the study had a history with keratoconus or were current wearers of rigid contact lenses.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!