Phytochemical investigation of the aerial roots of , a Cameroonian medicinal plant, resulted in a previously undescribed cerebroside, suroside , in addition to its aglycon congener suramide . Moreover, six known natural products including alpinumisoflavone , wighteone metabolite , oleanolic acid , -sitosterol , -sitosterol-3---D-glucopyranoside and epi--taraxastanolone were identified. The structures of the previously undescribed compounds were determined by analysis of 1D and 2D-NMR (One and two dimensional nuclear magnetic resonance), mass spectrometry, chemical conversion, and by comparison of these data with those from the literature. Wighteone metabolite exhibited a weak cytotoxic activity against the human HepG2 hepatocellular carcinoma cells with an IC value of 51.9 µM.
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http://dx.doi.org/10.1515/znc-2022-0165 | DOI Listing |
Chem Biodivers
September 2024
Department of Chemistry, Faculty of Science, University of Douala, P.O. Box 24157, Douala, Cameroon.
Based on ethnomedicinal and chemotaxonomic records of Ficus plants, Ficus sur Forssk was studied in the search for bioactive compounds. Eleven known compounds including mixture α -amyrin acetate and β -amyrin acetate (1 and 2), lupeol (3), 3β-acetoxy-olean-12-en-11-one (4), lupenyl acetate (5), taraxastan-3,20-diol (6), 3'- (3-methylbut-2-enyl) biochanin A (7), derrone (8), quercetin (9), stigmasterol (10), and stigmasterol glycoside (11) were isolated from stem barks of Ficus sur Forssk. Their structures were obtained through analysis of spectroscopic data 1D and 2D NMR), mass spectrometry, and by comparison of these data with the literature.
View Article and Find Full Text PDFMetabolites
November 2022
Pharmacognosy and Medicinal Plants Department, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo 11884, Egypt.
Four compounds, hippacine, 4,2'-dihydroxy-4'-methoxychalcone, 2',5'-dihydroxy-4-methoxychalcone, and wighteone, were selected from 4924 African natural metabolites as potential inhibitors against SARS-CoV-2 papain-like protease (PLpro, PDB ID: 3E9S). A multi-phased in silico approach was employed to select the most similar metabolites to the co-crystallized ligand () of the PLpro through molecular fingerprints and structural similarity studies. Followingly, to examine the binding of the selected metabolites with the PLpro (molecular docking.
View Article and Find Full Text PDFZ Naturforsch C J Biosci
May 2023
Department of Chemistry, Faculty of Science, University of Douala, P.O. Box 24157 Douala, Cameroon.
Phytochemical investigation of the aerial roots of , a Cameroonian medicinal plant, resulted in a previously undescribed cerebroside, suroside , in addition to its aglycon congener suramide . Moreover, six known natural products including alpinumisoflavone , wighteone metabolite , oleanolic acid , -sitosterol , -sitosterol-3---D-glucopyranoside and epi--taraxastanolone were identified. The structures of the previously undescribed compounds were determined by analysis of 1D and 2D-NMR (One and two dimensional nuclear magnetic resonance), mass spectrometry, chemical conversion, and by comparison of these data with those from the literature.
View Article and Find Full Text PDFAntioxidants (Basel)
January 2021
Department of Industrial Plant Science and Technology, College of Agricultural, Life and Environmental Sciences, Chungbuk National University, Cheongju 28644, Korea.
Plant extracts have gained more attention as natural therapeutic agents against inflammation characterized by an overproduction of several inflammatory mediators such as reactive oxygen species and pro-inflammatory cytokines. Although Nakai is generally known for its ornamental value, recent pharmacological research has demonstrated its potential therapeutic properties. Thus, to further evaluate the applicability of in the food, cosmetic, and medical industries, we identified the phytochemicals in three organ extracts (fruits: AF, branches: AB, leaves: AL) of .
View Article and Find Full Text PDFJ Asian Nat Prod Res
May 2017
f College of Pharmacy, Chungnam National University, Daejeon 34134 , Korea.
Inhibitory effects of NO production in RAW 264.7 macrophages guided the isolation of nine prenylated isoflavones, including a new cudraisoflavone L (1) and eight known metabolites furowanin B (2), erysubin A (3), wighteone (4), lupalbigenin (5), laburnetin (6), isolupalbigenin (7), 6,8-diprenylorobol (8), millewanin H (9) from the leaves of Cudrania tricuspidata. At the concentration of 10 μM, compounds 1, 2, and 4 significantly inhibited NO production with the inhibitory values of 72.
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