Protecting group free one-pot multicomponent Curtius reaction afforded a versatile MN type dendron, ensuring late-stage modification of both dendron and dendrimer to afford highly fluorescent symmetrical and unsymmetrical (Janus) polyurethane dendrimers. Fluorescence study of these dendrimers exhibited the Förster resonance energy transfer (FRET) between blue and mint green fluorophores.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9527571 | PMC |
| http://dx.doi.org/10.1039/d2ra04937f | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
A Novel PAMAM G3 Dendrimer-Based Foam with Polyether Polyol and Castor Oil Components as Drug Delivery System into Cancer and Normal Cells.
Materials (Basel)
August 2024
Medical College, University of Rzeszow, 1a Warzywna Street, 35-310 Rzeszow, Poland.
One of the intensively developed tools for cancer therapy is drug-releasing matrices. Polyamidoamine dendrimers (PAMAM) are commonly used as nanoparticles to increase the solubility, stability and retention of drugs in the human body. Most often, drugs are encapsulated in PAMAM cavities or covalently attached to their surface.
View Article and Find Full Text PDFDendritic polymer prodrug-based unimolecular micelles for pH-responsive co-delivery of doxorubicin and camptothecin with synergistic controlled drug release effect.
Colloids Surf B Biointerfaces
June 2024
State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, China. Electronic address:
Combination chemotherapy has been recognized as a more powerful strategy for tumor treatment rather than the single chemotherapy. However, the interactive mechanism of the two hydrophobic chemotherapeutic drugs has not been explored by now. Aiming for a better synergistic effect, such interactive mechanism was investigated in the present work, by designing CPT@DOX-DPU-PEG nanomedicine with encapsulated camptothecin (CPT) and conjugated doxorubicin (DOX).
View Article and Find Full Text PDFSynthesis of Fluorescent, Dumbbell-Shaped Polyurethane Homo- and Heterodendrimers and Their Photophysical Properties.
Int J Mol Sci
January 2023
Department of Chemistry and Biochemistry, Miami University, Oxford, OH 45056, USA.
Fluorescent dendrimers have wide applications in biomedical and materials science. Here, we report the synthesis of fluorescent polyurethane homodendrimers and Janus dendrimers, which often pose challenges due to the inherent reactivity of isocyanates. Polyurethane dendrons (G1-G3) were synthesized via a convergent method using a one-pot multicomponent Curtius reaction as a crucial step to establish urethane linkages.
View Article and Find Full Text PDFLow-generation fluorescent polyurethane dendrimers late-stage modification using azide-alkyne click chemistry.
RSC Adv
September 2022
Department of Chemistry and Biochemistry, Miami University Oxford OH 45056 USA
Protecting group free one-pot multicomponent Curtius reaction afforded a versatile MN type dendron, ensuring late-stage modification of both dendron and dendrimer to afford highly fluorescent symmetrical and unsymmetrical (Janus) polyurethane dendrimers. Fluorescence study of these dendrimers exhibited the Förster resonance energy transfer (FRET) between blue and mint green fluorophores.
View Article and Find Full Text PDFA Model for Late-Stage Modification of Polyurethane Dendrimers Using Thiol-Ene Click Chemistry.
ACS Omega
May 2021
Department of Chemistry and Biochemistry, Miami University, 501 E High Street, Oxford, Ohio 45056, United States.
Dendritic materials possessing urethane linkage are surprisingly more stable than similar structures having functional groups such as ether, ester, amide, or carbosilane. This generates profound interest in dendritic polyurethanes. Construction of a well-defined polyurethane dendrimer is, however, challenging because of isocyanates' high reactivity.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!