AI Article Synopsis
- The research focuses on isolating myrionsumamide A, a pair of enantiomeric alkaloids featuring a unique tetracyclic structure.
- These alkaloids were separated using chiral HPLC, achieving a 3:5 ratio from a scalemic mixture.
- The structure and configurations were identified via NMR spectroscopy, X-ray diffraction, and ECD calculations, with both enantiomers demonstrating antibacterial activity with a minimum inhibitory concentration (MIC) of 7.81 μg/ml.
Article Abstract
Investigation of the alkaloids from leads to the isolation of myrionsumamide A (1), a pair of enantiomeric alkaloids with an unprecedented tetracyclic system skeleton. These two alkaloids were separated by chiral HPLC with a ratio of 3 : 5 from the scalemic mixture. Their structures including absolute configurations were determined by NMR spectroscopy, X-ray diffraction data and ECD calculations. Both (+)-1 and (-)-1 showed antibacterial activity against with MIC at 7.81 μg ml.
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Source |
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9527643 | PMC |
| http://dx.doi.org/10.1039/d2ra05342j | DOI Listing |
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