Objective: To examine the prevalence of hip involvement between sexes in patients with ankylosing spondylitis (AS) treated with tumor necrosis factor inhibitors (TNFi) and to estimate the effect of TNFi on radiographic progression of hip involvement compared to the spine.
Methods: Two hundred ninety-nine patients with AS treated with TNFi (215 men; median age: 43 yrs [IQR 36-52], median disease duration: 7.6 yrs [IQR 2-15]) were evaluated for hip involvement, defined radiographically as Bath AS Radiological Hip Index (BASRI-hip) score ≥ 2. Those who received TNFi for ≥ 2 years (263/299) were assessed for radiographic progression. Radiographs of the pelvis and spine, obtained at baseline (ie, before TNFi initiation), were compared retrospectively to those obtained after 2.5 (SD 0.7) years and 7.0 (SD 2.3) years of TNFi treatment. Both hips were scored by BASRI-hip score and mean joint space width (MJSW). Spinal radiographs were scored by modified Stoke AS Spinal Score (mSASSS).
Results: The prevalence of hip involvement at baseline was 113/299 (38%) patients, of whom 87/215 (41%) were male and 26/84 (31%) were female ( = 0.10). In both sexes with hip involvement at baseline, BASRI-hip score and MJSW did not change significantly during follow-up. In males and females without baseline hip involvement, the BASRI-hip score remained unchanged after 2.5 (SD 0.7) years but increased significantly after 7.0 (SD 2.3) years, without reaching the cut-off of 2. In contrast, the MJSW slightly decreased at the 2 follow-up timepoints (ie, after 2.5 and 7.0 yrs). The mSASSS increased significantly during the follow-up in both sexes, regardless of hip involvement.
Conclusion: In our study, approximately one-third of patients with AS had hip involvement, which seemed to stabilize with TNFi treatment. No sex differences in the prevalence or progression of this manifestation were found.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.3899/jrheum.220061 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Org24598, a Selective Glycine Transporter 1 (GlyT1) Inhibitor, Reverses Object Recognition and Spatial Memory Impairments Following Binge-like Ethanol Exposure in Rats.
Molecules
December 2024
Department of Pharmacology and Pharmacodynamics, Medical University of Lublin, Chodzki 4a, 20-093 Lublin, Poland.
The N-methyl-D-aspartate (NMDA) glutamate receptor is a major target of ethanol, and it is implicated in learning and memory formation, and other cognitive functions. Glycine acts as a co-agonist for this receptor. We examined whether Org24598, a selective inhibitor of glycine transporter1 (GlyT1), affects ethanol withdrawal-induced deficits in recognition memory (Novel Object Recognition (NOR) task) and spatial memory (Barnes Maze (BM) task) in rats, and whether the NMDA receptor glycine site participates in this phenomenon.
View Article and Find Full Text PDFA Higher Charlson Comorbidity Index Is a Risk Factor for Hip Fracture in Older Adults During Low-Temperature Periods: A Cross-Sectional Study.
Medicina (Kaunas)
November 2024
Institute of Allied Health Sciences, College of Medicine, National Cheng Kung University, Tainan 701, Taiwan.
: The incidence of hip fractures is increasing, and there have been reports linking cold weather to a higher risk of fractures. This study aimed to evaluate clinical variables in hip fracture patients who may predispose them to such fractures under different temperatures. : This is a cross-sectional study conducted at a single medical center, enrolling older adults (≥60 years) who had experienced a hip fracture.
View Article and Find Full Text PDFIs Hip Muscle Flexibility Associated with Low Back Pain Among First-Year Undergraduate Students?
J Clin Med
December 2024
Department of Physical Therapy, Zefat Academic College, Zefat 13206, Israel.
Hip muscle lengthening is commonly associated with the normal function of the lumbar spine and lower extremities. Some evidence correlates hamstring and iliopsoas tightness with low back pain (LBP). Undergraduates are more prone to LBP as they are involved in prolonged sitting and poor posture.
View Article and Find Full Text PDFGender Differences in the Dynamics and Kinematics of Running and Their Dependence on Footwear.
Bioengineering (Basel)
December 2024
Division of Biomechatronics, Fraunhofer Institute for Manufacturing Engineering and Automation IPA, D-95447 Bayreuth, Germany.
Previous studies on gender differences in running biomechanics have predominantly been limited to joint angles and have not investigated a potential influence of footwear condition. This study shall contribute to closing this gap. Lower body biomechanics of 37 recreational runners (19 f, 18 m) were analysed for eight footwear and two running speed conditions.
View Article and Find Full Text PDFGenetic Associations of () and () with Prediabetes in the Ethnic Kazakh Population.
Diagnostics (Basel)
December 2024
Department of General Medical Practice, Semey Medical University, Semey 071400, Kazakhstan.
Background: This study aims to investigate the genetic contribution of polymorphic variants of the () and () genes to the risk of developing prediabetes in individuals of Kazakh ethnicity.
Materials And Methods: This was a case-control study involving 200 cases with prediabetes and 200 prediabetes-free controls, aged 16-60 years ( = 400). Real-time polymerase chain reaction on a StepOnePlus instrument (Applied Biosystems, USA), employing the TaqMan method for site-specific amplification and genotyping of the () and () genes was used.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!