A Comparative Metabolomics Approach Demonstrates That Octocrylene Accumulates in Tissues as Derivatives and That Octocrylene Exposure Induces Mitochondrial Dysfunction and Cell Senescence.

The objective of this work was to study the effect of octocrylene on and to compare the metabolomic response of this coral species to that obtained with . When coral was exposed to octocrylene, it accumulated octocrylene derivatives similar to . Octocrylene-fatty acid conjugates were found, as well as octocrylene heterosides. Furthermore, the tissue concentrations of various acylcarnitines and three sphingoid bases increased significantly. This phenomenon was indicative of mitochondrial dysfunction and the induction of cellular senescence processes in exposed corals. Overall, the responses of the two corals to octocrylene pollution were consistent. The proven impact of octocrylene on a second coral species suggests that potential environmental octocrylene pollution could impact many reef-building species. Furthermore, this work demonstrates that octocrylene may be modified by many organisms and that levels of octocrylene contamination in the food chain have probably been underestimated until now.