AI Article Synopsis

  • Changes in diet can negatively impact health, and the domestic silkworm (Bombyx mori) serves as a model to study this effect due to its simpler gut structure.
  • The study found that artificial diets led to reduced diversity in the intestinal bacteria of silkworms, causing microbial imbalances and increased disease susceptibility.
  • The research identifies key microbial genera that could help maintain intestinal balance, providing valuable insights for silkworm health and potential applications in other animals.

Article Abstract

Change in habitual diet may negatively affect health. The domestic silkworm (Bombyx mori) is an economically important oligophagous insect that feeds on mulberry leaves. The growth, development, and immune-disease resistance of silkworms have declined under artificial dietary conditions. In this study, we used as a model insect to explore the relationship between changes in diet and balance of intestinal microbes due to its simpler guts compared with those of mammals. We found that artificial diets reduced the intestinal bacterial diversity in silkworms and resulted in a simple intestinal microbial structure. By analyzing the correlations among food, gut, and fecal microbial diversity, we found that an artificial diet was more easily fermented and enriched the lactic acid bacteria in the gut of the silkworms. This diet caused intestinal acidification and microbial imbalance (dysbiosis). When combined with the artificial diet, Enterococcus mundtii, a colonizing opportunistic pathogen, caused dysbiosis and allowed the frequent outbreak of bacterial diseases in the silkworms. This study provides further systematic indicators and technical references for future investigations of the relationship between diet-based environmental changes and intestinal microbial balance. The body often appears unwell after habitual dietary changes. The domestic silkworm (Bombyx mori) raised on artificial diets is a good model to explore the relationship between dietary changes and the balance of intestinal microbes. In this study, the food-gut-feces microbial model was established, and some potential key genera that could regulate the balance of intestinal microbiota were screened out. Our findings will provide a reference for future research to further our understanding of healthy silkworm development and may even be useful for similar research on other animals.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9769633PMC
http://dx.doi.org/10.1128/spectrum.02357-22DOI Listing

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