AI Article Synopsis
- Developed two cost-effective methods for determining metoclopramide (MCP) in pharmaceuticals: a titrimetric method and a spectrophotometric method.
- The titrimetric method involves a reaction with potassium hydrogen peroxymonosulfate and uses iodometric back titration; the spectrophotometric method produces a chromogen for measurement at 350 nm.
- Both methods show reliable quantification capabilities, with specific ranges for MCP detection: 0.25-3.5 mg for titrimetric and 0.3-3.5 μg/mL for spectrophotometric, making them suitable for use in tablet and injection formulations.
Article Abstract
Objectives: To develop two (titrimetric and spectrophotometric) simple, rapid, sensitive and cost-effective methods for the determination of metoclopramide (MCP) in pharmaceutical dosage forms.
Materials And Methods: The titrimetric method (A) was based on the -oxidation reaction involving the use of potassium hydrogen peroxymonosulfate and subsequent iodometric back titration of a known residual reagent. The spectrophotometric method (B) was based on derivatization of MCP with potassium hydrogen peroxymonosulfate in the presence of iodide to produce a chromogen (triiodide) with a wavelength of maximum absorption at 350 nm.
Results: Method "A" was applicable over the concentration range of 0.25-3.5 mg to end volume 10 mL. In method "B", Beer's law was obeyed over the concentration range of 0.3-3.5 μg/mL with molar absorptivity of 24600 L/mol cm. The limits of quantification were calculated to be 0.25 mg/10 mL (A) and 0.2 μg/mL (B), respectively.
Conclusion: The proposed methods were suitable for determination of MCP as a pure substance in tablets and injection.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9634443 | PMC |
| http://dx.doi.org/10.4274/tjps.galenos.2021.33733 | DOI Listing |
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