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The Additive Impact of Transbronchial Cryobiopsy Using a 1.1-mm Diameter Cryoprobe on Conventional Biopsy for Peripheral Lung Nodules. | LitMetric

AI Article Synopsis

  • - The study evaluated the effectiveness and safety of sequential transbronchial cryobiopsy (TBC) combined with traditional transbronchial biopsy (TBB) using radial probe endobronchial ultrasound (RP-EBUS) for diagnosing small peripheral lung lesions (PLLs).
  • - Results showed that combining TBB and TBC increased the diagnostic yield to 79.1%, compared to 60.9% for TBB alone, with TBC contributing an 18.2% increase.
  • - The TBC technique provided larger tissue samples and had a low complication rate (10.5%), indicating it is a safe and effective method for improving diagnostic outcomes in patients with PLLs.

Article Abstract

Purpose: The diagnostic yield of transbronchial biopsy (TBB) using radial probe endobronchial ultrasound (RP-EBUS) is 71%, which is lower than that of transthoracic needle biopsy. We investigated the performance and safety of sequential transbronchial cryobiopsy (TBC) using a novel 1.1-mm diameter cryoprobe, after conventional TBB using RP-EBUS for the diagnosis of peripheral lung lesions (PLLs).

Materials And Methods: From April 2021 to November 2021, 110 patients who underwent bronchoscopy using RP-EBUS for the diagnosis of PLL ≤ 30 mm were retrospectively included in our study. All records were followed until June 2022.

Results: The overall diagnostic yield of combined TBB and TBC was 79.1%, which was higher than 60.9% of TBB alone (p=0.005). The diagnostic yield of sequential TBC was 65.5%, which increased the overall diagnostic yield by 18.2%. The surface area of tissues by TBC (mean area, 18.5 mm2) was significantly larger than those of TBB by 1.5-mm forceps (3.4 mm2, p < 0.001) and 1.9-mm forceps (3.7 mm2, p=0.011). In the multivariate analysis, PLLs with the longest diameter of ≤ 22 mm were found to be related to additional diagnostic benefits from sequential TBC (odds ratio, 3.51; 95% confidence interval, 1.043 to 11.775; p=0.042). Complications were found in 10.5% of the patients: pneumothorax (1.0%), infection (1.0%), and significant bleeding (8.6%). None of the patients developed any life-threatening complications.

Conclusion: Sequential TBC with a 1.1-mm cryoprobe improved the performance of conventional TBB using RP-EBUS without serious complications.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10101800PMC
http://dx.doi.org/10.4143/crt.2022.1008DOI Listing

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