AI Article Synopsis
- Inborn errors of immunity (IEI) are complex conditions that often lead to late diagnoses, with a rise in related inflammatory issues alongside infections.
- A case study of an adult showed that chronic Human Adenovirus C-1 arthritis was diagnosed in a patient with primary agammaglobulinemia, highlighting the challenges in managing these patients.
- The use of metagenomic next-generation sequencing provided an accurate diagnosis, and high-dose intravenous immunoglobulins led to complete recovery, emphasizing the need for advanced diagnostic techniques in treating immune-compromised individuals.
Article Abstract
Inborn errors of immunity (IEI) are a heterogeneous entity with an increasing number of late diagnoses. Besides infections, inflammatory manifestations are a growing part of the clinical landscape of IEI. These complications are of unknown causes and often lead to the prescription of immunosuppressive agents that worsen the underlying immune defect. We here report the case of an adult patient diagnosed with chronic Human Adenovirus C-1 arthritis in the setting of primary agammaglobulinemia. Metagenomic next-generation sequencing led to the correct diagnosis and high-dose intravenous immunoglobulins resulted in complete recovery. This observation gives new insights into adenoviral immunity and underlines the importance of metagenomics in the diagnosis of inflammatory manifestations in immunocompromised patients.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9623974 | PMC |
| http://dx.doi.org/10.1186/s12985-022-01905-z | DOI Listing |
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