Background: Anticoagulant treatment is recommended for at least three months after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-related acute pulmonary embolism (PE), but the persistent pulmonary clot burden after that time is unknown.
Methods: Lung perfusion was assessed by ventilation-perfusion (V/Q) SPECT/CT in 20 consecutive patients with SARS-CoV-2-associated acute PE after a minimum of three months anticoagulation therapy in a retrospective observational study.
Results: Remaining perfusion defects after a median treatment period of six months were observed in only two patients. All patients (13 men, seven women, mean age 55.6 ± 14.5 years) were on non-vitamin K direct oral anticoagulants (DOACs). No recurrent venous thromboembolism or anticoagulant-related bleeding complications were observed. Among patients with partial clinical recovery, high-risk PE and persistent pulmonary infiltrates were significantly more frequent (p < 0.001, respectively).
Interpretation: Temporary DOAC treatment seems to be safe and efficacious for resolving pulmonary clot burden in SARS-CoV-2-associated acute PE. Partial clinical recovery is more likely caused by prolonged SARS-CoV-2-related parenchymal lung damage rather than by persistent pulmonary perfusion defects.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9620596 | PMC |
| http://dx.doi.org/10.1186/s12931-022-02188-2 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Repetitive and extensive focused ultrasound-mediated bilateral frontal blood-brain barrier opening for Alzheimer's disease.
J Neurosurg
January 2025
4Department of Neurosurgery, Korea University Anam Hospital, Seoul, Republic of Korea.
Objective: Focused ultrasound (FUS)-mediated blood-brain barrier (BBB) opening is safe and potentially beneficial in patients with Alzheimer's disease (AD) for the removal of amyloid-beta (Aβ) plaques. However, the optimal BBB opening intervals and number of treatment sessions for clinical improvement remain undefined. Therefore, the aim of this study was to evaluate the safety and benefits of repeated and more extensive BBB opening alone.
View Article and Find Full Text PDFFitting of Soil-Water Characteristic Curves (SWCC) of Bukit Mewah, Malaysia soil using field monitoring dataset.
PLoS One
January 2025
Department of Civil and Environmental Engineering, Nazarbayev University, Nur-Sultan, Kazakhstan.
Rainfall-induced landslides are a frequent geohazard for tropical regions with prevalent residual soils and year-round rainy seasons. The water infiltration into unsaturated soil can be analyzed using the soil-water characteristic curve (SWCC) and permeability function which can be used to monitor and predict incoming landslides, showing the necessity of selecting the appropriate model parameter while fitting the SWCC model. This paper presents a set of data from six different sections of the studied slope at varying depths that are used to test the performance of three SWCC models, the van Genuchten-Mualem (vG-M), Fredlund-Xing (F-X) and Gardner (G).
View Article and Find Full Text PDFUnsupervised clustering of intraventricular hemodynamic forces for the phenotyping of left-ventricular function in non-ischemic left ventricular cardiomyopathy.
Eur Heart J Cardiovasc Imaging
January 2025
Vall d'Hebron Research Institute (VHIR), Barcelona, Spain.
Background: Cardiac magnetic resonance (CMR) is essential for diagnosing cardiomyopathy, serving as the gold standard for assessing heart chamber volumes and tissue characterization. Hemodynamic forces (HDF) analysis, a novel approach using standard cine CMR images, estimates energy exchange between the left ventricular (LV) wall and blood. While prior research has focused on peak or mean longitudinal HDF values, this study aims to investigate whether unsupervised clustering of HDF curves can identify clinically significant patterns and stratify cardiovascular risk in non-ischemic LV cardiomyopathy (NILVC).
View Article and Find Full Text PDFKnowledge, Attitude, and Practice of Patients Suffering From Sickle Cell Disease in an Endemic Zone.
J Pediatr Hematol Oncol
January 2025
Medical Oncology, Haemato-Oncology, BMT, Sarvodaya Hospital, Faridabad, Haryana, India.
Background And Objective: Sickle cell disease (SCD) is a genetically inherited disorder that is associated with morbidity and mortality.
Methods: This cross-sectional study was conducted on patients diagnosed with SCD to evaluate the knowledge, attitude, and practice of patients/guardians using a pretested questionnaire.
Results And Discussion: Of the 111 participants, 56 (50.
Comparison of Coconut and Sunflower Seed Oils in Improving the Skin Integrity and Weight Gain of Infants in the Neonatal ICU.
Adv Skin Wound Care
January 2025
Öznur Tiryaki, PhD, RN, is Associate Professor, Faculty of Health Sciences, Department of Midwifery, Sakarya University, Sakarya, Turkey. Hamide Zengin, PhD, RN, is Associate Professor, Faculty of Health Science, Department of Pediatric Nursing, Eskişehir Osmangazi University, Eskişehir, Turkey. Also at Sakarya University, Nursan Çınar, PhD, RN, is Professor, Faculty of Health Sciences, Department of Pediatric Nursing; Meltem Karabay, MD, is Associate Professor, Faculty of Medicine, Research and Training Hospital of Sakarya, Division of Neonatology, Department of Pediatrics; İbrahim Caner, MD, is Professor, Faculty of Medicine, Research and Training Hospital of Sakarya, Division of Neonatology, Department of Pediatrics; and Ertuğrul Güçlü, MD, is Professor, Faculty of Medicine, Department of Infectious Diseases and Clinical Microbiology.
Objective: To determine the effects of sunflower seed oil and coconut oil on the skin integrity and weight gain of preterm infants in the neonatal ICU.
Methods: In this randomized controlled trial, 66 preterm neonates (34-37 weeks' gestation) in the neonatal ICU of a training and research hospital were equally divided into three groups: sunflower seed oil, coconut oil, and control. The weights of neonates in all three groups were measured at admission to the neonatal ICU, at discharge, and at 1 month postdischarge.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!