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| http://dx.doi.org/10.3758/s13415-022-01045-5 | DOI Listing |
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Dipeptidyl peptidase-4 inhibitor linagliptin reduces inflammatory response, ameliorates tissue edema formation, and improves survival in severe sepsis.
Biomed Pharmacother
December 2024
Department of Research, Mount Sinai Medical Center, Miami Beach, FL, USA. Electronic address:
Background: Excessive inflammation in sepsis causes microvascular dysfunction associated with organ dysfunction and high mortality. The present studies aimed to examine the therapeutic potential of linagliptin, a dipeptidyl peptidase-4 (DPP-4) inhibitor in a clinically relevant polymicrobial sepsis model in mice.
Methods: Sepsis was induced by cecal ligation and puncture (CLP).
A COMPARATIVE STUDY OF CARDIOVASCULAR TOXICITY OF EPIRUBICIN AND DOXORUBICIN IN PATIENTS WITH BREAST CANCER.
Probl Radiac Med Radiobiol
December 2024
National Cancer Institute of the Ministry of Health of Ukraine, 33/43 33/43 Yulia Zdanovska Str., Kyiv, 03022, Ukraine.
Unlabelled: Patients with breast cancer (BC) are at high risk of cardiotoxicity (CT) due to combination of anticancer treatment.Cardio-vascular (СV) complications lead to the delay or discontinuation of anticancer therapy, which significantlyworsens the prognosis. Anthracyclines (AC) are the main drugs included in most anticancer treatment regimens.
View Article and Find Full Text PDFLEVELS AND RELATIVE RISKS OF MORTALITY OF CHORNOBYL CLEAN-UP WORKERS IN 1986-1987 YEARS FROM MAIN NON-NEOPLASTIC DISEASES (OBSERVATION PERIOD 1988-2021).
Probl Radiac Med Radiobiol
December 2024
State Institution «National Scientific Center for Radiation Medicine, Hematology and Oncology of the National Academy of Medical Sciences of Ukraine», 53 Yuriia Illienka Str., Kyiv, 04050, Ukraine.
Unlabelled: The emergency destruction of the 4th reactor of the Chornobyl nuclear power plant necessitated large-scale emergency work, which involved large contingents of specialists. Analysis the mortality of Chornobyl clean-up workers isan important and relevant basis for planning medical protection measures in conditions of a potential threat ofemergency and other radiation situations.The objective of this work is to determine the levels and relative risks of mortality of Chornobyl clean-up workers in1986-1987 years from major non-tumor diseases depending on the received dose of radiation exposure, taking intoaccount age and time after the accident (period of epidemiological studies 1988-2021).
View Article and Find Full Text PDFCortical hemodynamics of electrographic status epilepticus in the critically ill.
Epilepsia
December 2024
Department of Neurosciences, Université de Montréal, Montréal, Québec, Canada.
Objectives: The pathophysiological mechanisms of status epilepticus (SE) underlying potential brain injury remain largely unclear. This study aims to employ functional near-infrared spectroscopy (fNIRS) combined with video-electroencephalography (vEEG) to monitor brain hemodynamics continuously and non-invasively in critically ill adult patients experiencing electrographic SE. Our primary focus is to investigate neurovascular coupling and cerebrovascular changes associated with seizures, particularly during recurring and/or prolonged episodes.
View Article and Find Full Text PDFSafety of vaginal breech delivery following an unsuccessful external cephalic version: a comparative study.
Arch Gynecol Obstet
December 2024
Tel Aviv University School of Medicine, Tel Aviv, Israel.
Objective: To determine whether patients undergoing a trial of labor with a breech presentation following a failed attempt of external cephalic version (ECV) are at increased risk of adverse maternal and neonatal outcomes.
Methods: This retrospective cohort study was conducted at a single university-affiliated medical center. The study group comprised women with singleton pregnancies at term, categorized into three groups: those who underwent a failed external cephalic version (ECV) and subsequently attempted a trial of breech delivery (Breech-failed-ECV group), those who attempted an assisted vaginal breech delivery without a prior ECV attempt (Breech-no-ECV group), and those with vertex presentation following a successful ECV (Vertex-ECV).
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