Paraesophageal hernias (PEH) represent a small subset of all hiatal hernias. PEHs are often found incidentally during radiographic or endoscopic studies performed for another reason. While asymptomatic or minimally symptomatic PEHs can be safely observed with nonoperative management, the majority of patients with symptomatic PEHs will benefit from surgical repair, typically via a laparoscopic approach. The decision to pursue surgical repair of PEHs is dependent on a thorough evaluation of the patient's symptoms as well as an appropriate workup of the relevant anatomy. This study aims to review components of the clinical workup of PEHs. A review of the contemporary literature addressing the issue of diagnostic workup of patients with PEHs was performed. Information from available studies were collected and organized into a brief review format. Two key principles of the diagnostic evaluation of patients with PEHs include (1) establishing a link between patient symptoms and the PEH, and (2) identifying abnormal anatomy or physiology that may impact surgical repair (e.g., Barrett esophagus, esophageal stricture or diverticulum, delayed gastric emptying). While a multitude of radiographic, endoscopic, and functional testing options are available to evaluate PEH, selection of the appropriate test is dependent on patient clinical presentation. Successful management of PEHs depends on a thorough evaluation of patient symptoms and hernia anatomy. Therefore, patients with PEHs should undergo a history and physical examination, upper endoscopy, and obtain radiographic evaluation of the PEH (e.g., barium esophagram, computed tomography scan). Further testing should be directed by patient symptoms, especially in the case of discordance between symptoms and imaging findings.
Download full-text PDF |
Source |
---|---|
http://dx.doi.org/10.1089/lap.2022.0403 | DOI Listing |
Pharmaceutics
December 2024
Laboratorio RAMSES, IRCCS Istituto Ortopedico Rizzoli, Via di Barbiano, 1/10, 40136 Bologna, Italy.
The treatment of articular cartilage damage has always represented a problem of considerable practical interest for orthopedics. Over the years, many surgical techniques have been proposed to induce the growth of repairing tissue and limit degeneration. In 1994, the turning point occurred: implanted autologous cells paved the way for a new treatment option based more on regeneration than repair.
View Article and Find Full Text PDFPolymers (Basel)
December 2024
School of Biomedical Engineering and Imaging, Xianning Medical College, Hubei University of Science and Technology, Xianning 437100, China.
Powder-based hemostatic materials have offered unprecedented opportunities for the effective sealing and repair of irregularly shaped wounds and high-pressure, noncompressible arterial bleeding wounds caused by surgeries, traffic accidents, and wartime injuries. However, inadequate adhesion to bleeding wounds and poor hemostasis in biological tissues remains challenging. Herein, we report a self-gelling hemostatic powder based on polyacrylic acid/polyethyleneimine/polyethylene glycol (named PPG) for rapid hemostasis and effective antibacterial ability.
View Article and Find Full Text PDFNutrients
December 2024
Department of Molecular Biology and Genetics, Çanakkale Onsekiz Mart University, Çanakkale 17100, Turkey.
The brain contains many interconnected and complex cellular and molecular mechanisms. Injury to the brain causes permanent dysfunctions in these mechanisms. So, it continues to be an area where surgical intervention cannot be performed except for the removal of tumors and the repair of some aneurysms.
View Article and Find Full Text PDFInt J Mol Sci
December 2024
Departments of Genetics, Microbiology and Immunology, Center for Research on Harmful Effects of Biological and Chemical Hazards, Faculty of Medical Sciences, University of Kragujevac, 69 Svetozara Markovica Street, 34000 Kragujevac, Serbia.
Primary Sjögren's syndrome (pSS) is an autoimmune disease characterized by the infiltration of lymphocytes on salivary and lacrimal glands, resulting in their dysfunction. Patients suffering from severe pSS have an increased risk of developing multi-organ dysfunction syndrome due to the development of systemic inflammatory response, which results in immune cell-driven injury of the lungs, kidneys, liver, and brain. Therapeutic agents that are used for the treatment of severe pSS encounter various limitations and challenges that can impact their effectiveness.
View Article and Find Full Text PDFInt J Mol Sci
December 2024
Department of Diagnostic Pathology and Genome Medical Center, Kindai University Hospital, Osaka-sayama 589-8511, Osaka, Japan.
DNA is frequently damaged by genotoxic stresses such as ionizing radiation, reactive oxygen species, and nitrogen species. DNA damage is a key contributor to cancer initiation and progression, and thus the precise and timely repair of these harmful lesions is required. Recent studies revealed transcription as a source of genome instability, and transcription-coupled DNA damage has been a focus in cancer research.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!