A new catalytic method for borylation of unprotected anilines is described. The catalytic method is developed by designing a new type of ligand framework that enables borylation at room temperature. We showed that whereas previously reported borylation of 2-substituted anilines required multistep protection/deprotection sequences and a high reaction temperature, our method gives a straightforward solution for achieving borylation without such protection/deprotection chemistry at room temperature.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1021/acs.orglett.2c03188 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Ultralight Carbon Tube Foam-Derived SiC Nanofibrous Aerogels with Arbitrary Shape, Excellent Rigidity, and Resilience for Thermal Insulation.
ACS Appl Mater Interfaces
January 2025
School of Mechanics and Aerospace Engineering, Dalian University of Technology, Dalian 116024, P. R. China.
Ceramic aerogels are promising high-temperature thermal insulation materials due to their outstanding thermal stability and oxidation resistance. However, restricted by nanoparticle-assembled network structures, conventional ceramic aerogels commonly suffer from inherent brittleness, volume shrinkage, and structural collapse at high temperatures. Here, to overcome such obstacles, 3D ultralight and highly porous carbon tube foams (CTFs) were designed and synthesized as the carbonaceous precursors, where melamine foams were used as the sacrificial templates to form the hollow and thin-wall network structures in the CTFs (density: ∼4.
View Article and Find Full Text PDFRapid fabrication and dissolution of pressed Ni/Mg matrix targets for Co production.
EJNMMI Radiopharm Chem
January 2025
Department of Nuclear Medicine and Medical Physics, Karolinska University Hospital, Stockholm, 171 76, Sweden.
Background: Beyond the use of conventional short-lived PET radionuclides, there is a growing interest in tracking larger biomolecules and exploring radiotheranostic applications. One promising option for imaging medium-sized molecules and peptides is ⁵⁵Co (T₁/₂ = 17.5 h, β⁺ = 76%), which enables imaging of new and already established tracers with blood circulation of several hours.
View Article and Find Full Text PDFAnalytical Validation and Performance of a Blood-Based P-tau217 Diagnostic Test for Alzheimer Disease.
J Appl Lab Med
January 2025
Eli Lilly and Company, Indianapolis, IN, United States.
Background: Blood-based biomarkers, especially P-tau217, have been gaining interest as diagnostic tools to measure Alzheimer disease (AD) pathology.
Methods: We developed a plasma P-tau217 chemiluminescent immunoassay using 4G10E2 and IBA493 as antibodies, a synthetic tau peptide as calibrator, and the Quanterix SP-X imager. Analytical validation performed in a College of American Pathologists-accredited CLIA laboratory involved multiple kit lots, operators, timepoints, and imagers.
Characterization of a simple gas expansion ion source for intense pulses of subthermal molecular ions.
Rev Sci Instrum
January 2025
Max-Planck-Institut für Kernphysik, Saupfercheckweg 1, 69117 Heidelberg, Germany.
We describe a simple gas expansion ion source based on static discharge voltages and a commercially available pulsed valve. The discharge is initiated by the gas pulse itself between two high voltage electrodes, without the need for fast voltage switches or complex timing schemes. The ion source very reliably produces intense bursts of molecular ions (with currents exceeding 100 μA during the pulse-on phase) with only minor pulse-to-pulse variations in intensity and pulse shape.
View Article and Find Full Text PDFPhase formation and phase stability for the homogenous and heterogeneous amorphous metals versus the crystalline phase.
Proc Natl Acad Sci U S A
January 2025
Department of Materials Science and Engineering, Iowa State University, Ames, IA 50011.
From molecular dynamics (MD) simulations of melt-quenching and thermal aging procedures in pure Ag, Cu, Ag-Cu binary alloys, and Cu-Zr binary alloys, we have identified two distinct amorphous phases for a metastable undercooled liquid: the homogeneous L-phase with low shear rigidity and the heterogenous G-phase with much higher shear rigidity and a heterogeneity length scale Λ. Here, we examine two-phase equilibration studies showing that the G-phase melts to form the L-phase above ~1,000 K, which then transforms to form the crystal (X) phase; however, below the melting point of the G-Phase (~990 K), the X- and G-phases do not transform into each other. We suggest the presence of a G-phase is likely responsible for embrittlement often observed in metallic glasses.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!