AI Article Synopsis
- Vitamin D signaling through the vitamin D receptor (VDR) is crucial in the development and spread of cancer, particularly in breast cancer.
- This study examined VDR levels in 15 pairs of primary breast cancer and bone metastasis tissue samples, along with additional samples from patients without metastases.
- The findings revealed that VDR expression was significantly lower in bone metastases compared to primary tumors, suggesting that reduced VDR levels may promote cancer progression and spread.
Article Abstract
There is ample evidence today that vitamin D signalling via the vitamin D receptor (VDR) plays a pivotal role in cancer growth and metastasis. The aim of this study was to analyse VDR expression of primary breast cancer and corresponding bone metastases tissue samples. Collectively, 15 sample pairs and 11 samples of patients that did not develop metastases were analysed histologically for VDR expression (n = 41). Overall, VDR expression was significantly lower in bone metastases compared to primary tumour samples ( < .0001). Downregulation of the VDR in breast cancer cells may define a critical turning point in oncogenesis that accelerates cancer cell dissemination and metastases.
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| http://dx.doi.org/10.1080/07357907.2022.2142604 | DOI Listing |
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