AI Article Synopsis
- Following Kasai hepatic portoenterostomy, most biliary atresia patients will need liver transplants due to ongoing liver issues, making prevention and delay of transplants crucial for better outcomes.
- This review covers common therapies used after HPE and evaluates the evidence behind them.
- It also explores new management strategies through an analysis of recent clinical trials and potential beneficial therapies from other liver diseases.
Article Abstract
Following Kasai hepatic portoenterostomy (HPE), most patients with biliary atresia will eventually require liver transplantation due to progressive cirrhosis and liver failure. Preventing liver transplantation, or even delaying eventual liver transplantation, is the key to improving long-term outcomes. This review first examines the commonly used adjuvant therapies in post-HPE biliary atresia and the strength of the evidence supporting these therapies. Next, it examines the evolving frontiers of management through a comprehensive evaluation of both recently completed and ongoing clinical trials in biliary atresia. Promising therapies used in other cholestatic liver diseases with potential benefit in biliary atresia are discussed. Improving post-HPE management is critical to prevent complications, delay liver transplantation, and ultimately improve the long-term survival of patients with biliary atresia.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9614654 | PMC |
| http://dx.doi.org/10.3389/fped.2022.1007813 | DOI Listing |
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