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Highly diverse ribonucleic acid viruses in the viromes of eukaryotic host species in Yunnan province, China. | LitMetric

Highly diverse ribonucleic acid viruses in the viromes of eukaryotic host species in Yunnan province, China.

Front Microbiol

National Laboratory for Poliomyelitis, WHO Western Pacific Region Office (WPRO) Regional Polio Reference Laboratory, National Health Commission (NHC) Key Laboratory for Biosafety, NHC Key Laboratory for Medical Virology, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China.

Published: October 2022

AI Article Synopsis

  • - The research focuses on understanding the evolutionary characteristics of diverse RNA viruses found in various animal species, highlighting the importance of studying the virome in Yunnan, China.
  • - Using metagenomic next-generation sequencing, the study analyzed 465 specimens from bats, pangolins, monkeys, and more, identifying several RNA viruses, including five newly discovered Alphacoronavirus strains.
  • - Findings revealed significant genetic divergence and potential new viral species, raising awareness of the evolutionary dynamics among viruses, and the need for further research in this area.

Article Abstract

Background: The diversity in currently documented viruses and their morphological characteristics indicates the need for understanding the evolutionary characteristics of viruses. Notably, further studies are needed to obtain a comprehensive landscape of virome, the virome of host species in Yunnan province, China.

Materials And Methods: We implemented the metagenomic next-generation sequencing strategy to investigate the viral diversity, which involved in 465 specimens collected from bats, pangolins, monkeys, and other species. The diverse RNA viruses were analyzed, especially focusing on the genome organization, genetic divergence and phylogenetic relationships.

Results: In this study, we investigated the viral composition of eight libraries from bats, pangolins, monkeys, and other species, and found several diverse RNA viruses, including the Alphacoronavirus from bat specimens. By characterizing the genome organization, genetic divergence, and phylogenetic relationships, we identified five Alphacoronavirus strains, which shared phylogenetic association with Bat-CoV-HKU8-related strains. The pestivirus-like virus related to recently identified Dongyang pangolin virus (DYPV) strains from dead pangolin specimens, suggesting that these viruses are evolving. Some genomes showed higher divergence from known species (e.g., calicivirus CS9-Cali-YN-CHN-2020), and many showed evidence of recombination events with unknown or known strains (e.g., mamastroviruses BF2-astro-YN-CHN-2020 and EV-A122 AKM5-YN-CHN-2020). The newly identified viruses showed extensive changes and could be assigned as new species, or even genus (e.g., calicivirus CS9-Cali-YN-CHN-2020 and iflavirus Ifla-YN-CHN-2020). Moreover, we identified several highly divergent RNA viruses and estimated their evolutionary characteristics among different hosts, providing data for further examination of their evolutionary dynamics.

Conclusion: Overall, our study emphasizes the close association between emerging viruses and infectious diseases, and the need for more comprehensive surveys.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9606678PMC
http://dx.doi.org/10.3389/fmicb.2022.1019444DOI Listing

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