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Legionnaires' disease (LD), caused by , including the most prevalent , has been treated primarily with antibiotics. Environmental water and soil are the reservoirs for . Studying antimicrobial susceptibility using a large number of isolates from various environmental sources and regions could provide an unbiased result. In the present study, antimicrobial susceptibility of 1464 environmental isolates that were derived from various environmental water and soil sources of 12 cities in China to rifampin (RIF), erythromycin (ERY), clarithromycin (CLA), azithromycin (AZI), ciprofloxacin (CIP), moxifloxacin (MOX), levofloxacin (LEV), and doxycycline (DOX) was investigated, and minimum inhibitory concentration (MIC) data were obtained. We show that regarding macrolides, ERY was least active (MIC = 0.5 mg/L), while CLA was most active (MIC = 0.063 mg/L). A total of three fluoroquinolones have similar MICs on . Among these antimicrobials, RIF was the most active agent, while DOX was the most inactive one. We observed different susceptibility profiles between serogroup 1 (sg1) and sg2-15 or between water and soil isolates from different regions. The ECOFFs were ERY and AZI (0.5 mg/L), RIF (0.002 mg/L), CIP, CLA and MOX (0.125 mg/L), LEV (0.063 mg/), and DOX (32 mg/L). Overall, two fluoroquinolone-resistant environmental isolates (0.14%) were first documented based on the wild-type MIC distribution. Not all azithromycin-resistant isolates (44/46, 95.65%) harbored the efflux pump. The MICs of the ERY and CLA on the + isolates were not elevated. These results suggested that the efflux pump might be only responsible for AZI resistance, and undiscovered AZI-specific resistant mechanisms exist in . Based on the big MIC data obtained in the present study, the same defense strategies, particularly against both CLA and RIF, may exist in . The results determined in our study will guide further research on antimicrobial resistance mechanisms of and could be used as a reference for setting clinical breakpoints and discovering antimicrobial-resistant isolates in the clinic, contributing to the antibiotic choice in the treatment of LD.
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http://dx.doi.org/10.3389/fmicb.2022.924709 | DOI Listing |
Mikrochim Acta
December 2024
Chemistry Department, Faculty of Science, Tanta University, Tanta, Egypt.
The detection of 4-chloro-2-methylphenoxyacetic acid (CMPA) herbicide is crucial due to the potential health risks linked to exposure through drinking water, air, and food, which may adversely affect liver and kidney functions. To address this environmental concern and promote sustainable agriculture, a sensitive carbon paste sensor incorporating a composite material was developed. The composite sensor is based on porous cobalt-1,4-benzenedicarboxylate metal-organic framework and exfoliated montmorillonite nanolayers (Co-OF/MMt).
View Article and Find Full Text PDFCurr Microbiol
December 2024
School of Bio Science and Technology, VIT University, Vellore, Tamil Nadu, 632014, India.
Pseudomonas aeruginosa is a prevalent nosocomial pathogen and a significant reservoir of antimicrobial resistance genes in residential and built environments. It is also widespread in various indoor and outdoor settings, including sewage, surface waters, soil, recreational waters (both treated and untreated), and industrial effluents. Surveillance efforts for P.
View Article and Find Full Text PDFPlant Physiol Biochem
December 2024
Key Laboratory of Herbage Improvement and Grassland Agroecosystems, Lanzhou University, Lanzhou, 730020, China; Key Laboratory of Grassland Livestock Industry Innovation, Ministry of Agriculture and Rural Affairs, Lanzhou, 730020, China; College of Pastoral Agriculture Science and Technology, Lanzhou University, Lanzhou, 730020, China; Engineering Research Center of Grassland Industry, Ministry of Education, Gansu Tech Innovation Centre of Western China Grassland Industry, China. Electronic address:
Arbuscular mycorrhizal (AM) fungi are widely existing soil microorganisms that form symbiotic relationships with most terrestrial plants. They are important for enhancing adversity resistance, including resistance to disease and water stresses. Nevertheless, it is not clear whether the benefits can be maintained in regulating the occurrence of plant diseases under drought, flooding stress and during water restoration.
View Article and Find Full Text PDFPlant Cell Environ
December 2024
Department of Environmental Physics and Irrigation, Institute of Soil, Water and Environment Sciences, Volcani Center, Rishon LeZion, Israel.
Plant Cell Environ
December 2024
Biological Sciences, School of Natural Sciences, University of Tasmania, Hobart, Tasmania, Australia.
Vapour pressure deficit (VPD) is a primary determinant of stomatal behaviour and water balance in plants. With increasing global temperature, the accompanying rise in VPD is likely to have a significant impact on the performance of plant species in the future. However, the plasticity of stomatal response to VPD remains largely unexplored.
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