Among the many clinical decision support (CDS) mechanisms available in electronic health record (EHR) systems, dose range checking (DRC) is one of the most impactful safeguard tools integrated within most computerized provider order entry (CPOE) workflows. Unfortunately, improper configurations and lack of resources to maintain and monitor CDS systems can hinder and even disrupt daily clinical operations. This article seeks to highlight the impact that informatics pharmacists can make by implementing different strategies to decrease nuisance alerts and create clinically meaningful DRC alerts that guide clinicians in their practice. Following the activation of the DRC application for 3623 medication groupers (ie, generic drugs and all their dosage form variations), informatics pharmacists implemented strategies to monitor DRC alert output and decrease the number of inappropriate alerts. Such strategies included weekly monitoring of alerts, modification of order sentences (including dose, route, and age/weight filters), update to the rule triggering the alerts, and modifications of the preference settings. From July to September 2018, an average of 70 DRC tables were reviewed by informatics pharmacists, reducing the number of overridden DRC alerts to 4796 in the first week of September-a 63% decrease in a 3-month period. By reducing the number of DRC nuisance alerts and improving the clinical content of DRC alerts, informatics pharmacists can contribute to lowering alert fatigue and improving providers' trust in CDS alerts.
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http://dx.doi.org/10.1177/87551225221117152 | DOI Listing |
Clin Pharmacol Ther
January 2025
Division of Clinical Pharmacology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Pharmacogenetic testing can prevent severe toxicities from several oncology drug therapies; it also has the potential to improve the outcomes from supportive care drugs. Paired tumor and germline sequencing is increasingly common in oncology practice; these include sequencing of pharmacogenes, but the germline pharmacogenetic variants are rarely included in the clinical reports, despite many being clinically actionable. We established an informatics workflow to evaluate the clinical sequencing results for pharmacogenetic variants.
View Article and Find Full Text PDFJAMA Netw Open
January 2025
HealthPartners Institute, Bloomington, Minnesota.
Importance: Medication adherence is important for managing blood pressure (BP), low-density lipoprotein cholesterol (LDL-C), and hemoglobin A1c (HbA1c). Interventions to improve medication adherence are needed.
Objective: To examine the effectiveness of an intervention using algorithmic identification of low medication adherence, clinical decision support to physicians, and pharmacist outreach to patients to improve cardiometabolic medication adherence and BP, LDL-C, and HbA1c control.
Med Sci Monit
January 2025
School of Public Health, Centre of Postgraduate Medical Education of Warsaw, Warsaw, Poland.
BACKGROUND Dietary supplements (DS) are increasingly popular worldwide, with 78% of Polish adults reporting their use, and nearly half using them regularly. The wide availability, selection, and affordability contribute to this prevalence. However, misinformation and potential health risks from incorrect usage highlight the importance of health literacy in making informed choices about DS.
View Article and Find Full Text PDFInt J Clin Pharm
January 2025
Pharmacy Practice and Pharmacotherapeutics Department, College of Pharmacy, University of Sharjah, Sharjah, United Arab Emirates.
Background: Fragmented healthcare systems hinder pharmacists' access to comprehensive patient data, limiting their clinical role and posing health risks. Enhancing system interoperability and evaluating factors influencing pharmacists' readiness for technology-driven practice change is a crucial step.
Aim: This systematic review aimed to investigate the digital determinants of pharmacists' readiness for technology-oriented practice change and interoperability.
Am J Pharm Educ
November 2024
University of Maryland School of Pharmacy, Baltimore, MD, USA.
Objective: This study examined the alignment between and changes within the tasks performed by pharmacists and skills sought by pharmacist employers from 2012 to 2022.
Methods: The United States Department of Labor's Occupational Information Network (O*NET) surveys a random sample of employees in targeted occupations every 5 years and provides a publicly available database allowing exploration of the frequency with which essential tasks are performed and perceived relevance and importance. Lightcast (formerly Burning Glass) provides labor market analytics of job advertisements; cross-sectional and longitudinal data can be filtered according to occupation, industry, location, and area of specialty.
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