The present study was conducted to determine the antidiabetic effect of Momordica charantia (MC) on pancreatic islets of Langerhans in streptozotocin (STZ)-induced diabetic male Wistar rats in relation to the distribution of insulin immuno-positive beta cells. MC was fed to rats at 2, 5, and 10% of the standard diet for 12 wk. After sacrification, the pancreatic tissues were obtained for histopathological and immunohistochemical observations. In addition, monitoring of fasting blood glucose was applied each month during experimental period. The results revealed that the oral doses of MC at 5% and 10% of the daily diet increased the percentage of insulin-positive pancreatic beta cells as well as the size and number of pancreatic islets. Moreover, significant (p≤0.0001) dose and time-depended reduction in fasting blood glucose levels were observed. In conclusion, these results suggest that MC induces antidiabetic effects via regeneration of insulin-positive pancreatic beta cells and increase the number of insulin secretory granules hence, blood glucose reduction.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.3177/jnsv.68.438 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Selenium Enhances the Growth of Bovine Endometrial Stromal Cells by PI3K/AKT/GSK-3β and Wnt/β-Catenin Pathways.
Vet Sci
December 2024
College of Veterinary Medicine, Yangzhou University, Yangzhou 225009, China.
The bovine uterus is susceptible to bacterial infections after calving, particularly from (), which often results in endometritis. Additionally, postpartum stress in cows can elevate cortisol levels in the body, inhibiting endometrial regeneration and reducing immune function, thereby further increasing the risk of infection. Selenium (Se) is a common feed additive in dairy farming, known for its anti-inflammatory and antioxidant effects.
View Article and Find Full Text PDFThe Potential Influence of the Presence of Mycotoxins in Human Follicular Fluid on Reproductive Outcomes.
Toxins (Basel)
November 2024
Department of Obstetrics and Gynecology, Semmelweis University, 1088 Budapest, Hungary.
The effect of mycotoxin exposure on follicular fluid composition and reproductive outcomes in women undergoing in vitro fertilisation (IVF) was investigated in this study. Twenty-five patients were included, and follicular fluid and serum samples were analysed for various mycotoxins. Principal observations:1.
View Article and Find Full Text PDFReproductive Health in Women with Major β-Thalassemia: Evaluating Ovarian Reserve and Endocrine Complications.
Metabolites
December 2024
IVF Unit, Department of Obstetrics and Gynecology, Faculty of Medicine, School of Health Sciences, University of Thessaly, 41110 Larissa, Greece.
Thalassemia is an autosomal recessive hereditary chronic hemolytic anemia characterized by a partial or complete deficiency in the synthesis of alpha- or beta-globin chains, which are essential components of adult hemoglobin. Mutations in the globin genes lead to the production of unstable globin chains that precipitate within cells, causing hemolysis. This shortens the lifespan of mature red blood cells (RBCs) and results in the premature destruction of RBC precursors in the bone marrow.
View Article and Find Full Text PDFThe Role of Beta-Hydroxybutyrate in Mitigating the Inflammatory and Metabolic Consequences of Uric Acid.
Metabolites
December 2024
Department of Cell Biology and Physiology, Brigham Young University, Provo, UT 84602, USA.
Uric acid (UA), a metabolite of purine and fructose metabolism, is linked to inflammation and metabolic disorders, including gout and cardiovascular disease. Its pro-inflammatory effects are largely driven by the activation of the nucleotide-binding oligomerization domain-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome, leading to increased cytokine production. Beta-hydroxybutyrate (BHB), a ketone produced during fasting or carbohydrate restriction, has been shown to reduce inflammation.
View Article and Find Full Text PDFOptimization of Protoplast Preparation Conditions in and Transcriptomic Analysis Throughout the Process.
J Fungi (Basel)
December 2024
College of Agriculture, Yanbian University, Yanji 133002, China.
Protoplasts are essential tools for genetic manipulation and functional genomics research in fungi. This study systematically optimized protoplast preparation conditions and examined transcriptional changes throughout the preparation and regeneration processes to elucidate the molecular mechanisms underlying the formation and regeneration of protoplasts in . The results indicated an optimal protoplast yield of 5.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!