The purpose of this in vitro study was to compare the fracture resistance and survival of various esthetic crowns for primary molars after artificial aging via chewing simulation. A typodont tooth (mandibular primary second molar) was prepared to receive five different types of crowns as follows (n equals 10): prefabricated fiberglass (PF); CAD/CAM zirconia (CZ); CAD/CAM resin-ceramic (CR); composite- strip (CS); and prefabricated zirconia (PZ) as control. All specimens were subjected to 750,000 cycles of thermomechanical loading to artificially simulate three years of clinical service. None of the crowns from the CS group survived artificial aging. Surviving crowns were evaluated via micro-CT considering microcrack formation, and a load-to-fracture test was applied. Data were analyzed using one-way analysis of variance followed by the Duncan test. Group PZ (557.4±170.1 N) and CR (669.6±255.2) were found to have comparable results (P >0.05), which were lower than the other groups (P<0.05). Group CZ resulted in the highest mean load-to-fracture value (1126.2±180.6; P <0.05). At the end of three years of artificial aging, microcracks were observed for only CS and PF groups. These in vitro data suggest that all tested crowns, except CS crowns, survived three years of artificial aging; however, CAD/CAM zirconia crowns may provide longer service, as they showed the highest fracture resistance with no microcrack formation.
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Acta Ophthalmol
December 2024
Department of Ophthalmology and Optometry, Medical University of Vienna, Vienna, Austria.
Purpose: The relationship between retinal morphology, as assessed by optical coherence tomography (OCT), and retinal function in microperimetry (MP) has not been well studied, despite its increasing importance as an essential functional endpoint for clinical trials and emerging therapies in retinal diseases. Normative databases of healthy ageing eyes are largely missing from literature.
Methods: Healthy subjects above 50 years were examined using two MP devices, MP-3 (NIDEK) and MAIA (iCare).
Nurs Rep
December 2024
School of Data Science and Analytics, Kennesaw State University, Kennesaw, GA 30144, USA.
Background/objectives: The projected increase from 58 million older adults in 2022 to 82 million by 2050 in the United States highlights the urgency of preparing nursing students to care for this aging population. However, studies reveal negative attitudes among nursing students toward older adults. A three-phased educational intervention that included an artificial intelligence (AI)-driven virtual simulation was implemented to address this.
View Article and Find Full Text PDFJ Imaging
December 2024
College of Electrical and Information, Northeast Agricultural University, 600 Changjiang Road, Harbin 150038, China.
Alzheimer's disease (AD), a degenerative condition affecting the central nervous system, has witnessed a notable rise in prevalence along with the increasing aging population. In recent years, the integration of cutting-edge medical imaging technologies with forefront theories in artificial intelligence has dramatically enhanced the efficiency of identifying and diagnosing brain diseases such as AD. This paper presents an innovative two-stage automatic auxiliary diagnosis algorithm for AD, based on an improved 3D DenseNet segmentation model and an improved MobileNetV3 classification model applied to brain MR images.
View Article and Find Full Text PDFJ Neuropathol Exp Neurol
December 2024
Department of Pathology, Molecular and Cell-Based Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, United States.
Although Alzheimer disease neuropathologic change (ADNC) is the most common pathology underlying clinical dementia, the presence of multiple comorbid neuropathologies is increasingly being recognized as a major contributor to the worldwide dementia burden. We analyzed 1051 subjects with specific combinations of isolated and mixed pathologies and conducted multivariate logistic regression analysis on a cohort of 4624 cases with mixed pathologies to systematically explore the independent cognitive contributions of each pathology. Alzheimer disease neuropathologic change and limbic-predominant age-related TDP-43 encephalopathy neuropathologic change (LATE-NC) were both associated with a primary clinical diagnosis of Alzheimer disease (AD) and were characterized by an amnestic dementia phenotype, while only ADNC associated with logopenic variant primary progressive aphasia (PPA).
View Article and Find Full Text PDFAudiol Res
December 2024
Starkey Hearing, Eden Prairie, MN 55344, USA.
Despite the significant advancements in hearing aid technology, their adoption rates remain low, with stigma continuing to be a major barrier for many. This review aims to assess the origins and current state of hearing aid stigma, as well as explore potential strategies for alleviating it. This review examines the societal perceptions, psychological impacts, and recent technological advancements that can influence hearing aid adoption and reduce stigma.
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