Significant association between and gene polymorphisms and chronic spontaneous urticaria in a Colombian Caribbean population.

Introduction: Chronic spontaneous urticaria (CSU) is an inflammatory skin disease related to poor quality of life. Previous studies have found that vitamin D deficiency and vitamin D receptor () , and gene single-nucleotide polymorphisms (SNPs) influence immune response and susceptibility to skin disorders.

Aim: To explore the role of SNPs, and the association of vitamin D serum levels in a sample of Colombian Caribbean CSU patients. : It is a case-control study. A group of CSU patients (n = 100) was compared with healthy individuals as a control group (n = 100). polymorphisms were genotyped by quantitative polymerase chain reaction and Taqman probes. Allelic, genotypic, and haplotype associations were estimated. Serum vitamin D levels were measured using enzyme-linked-immunosorbent serologic assay.

Results: Compared to the control group, the presence of G allele in and A allele in SNPs of gene was found to be a risk factor for CSU (odds ratio (OR) estimated using logistic regression adjusted by gender: 2.08 and 1.61, respectively, all P values < 0.05). The individuals who carry haplotype showed decrease in vitamin D levels (11.34 ng/mL; P = 0.002) with the G allele of and A allele of gene SNPs.

Conclusion: We reported for the first time the association of [rs731236] and [rs2228570] gene SNPs showing as a risk factor for CSU in a sample of multiethnic patients from the Colombian Caribbean population.