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Differential Gene Expression in Late-Onset Friedreich Ataxia: A Comparative Transcriptomic Analysis Between Symptomatic and Asymptomatic Sisters.
Int J Mol Sci
October 2024
Division of Biotechnologies, Italian National Agency for New Technologies, Energy and Sustainable Development (ENEA), 00123 Rome, Italy.
Friedreich ataxia (FRDA) is the most common inherited ataxia, primarily impacting the nervous system and the heart. It is characterized by GAA repeat expansion in the FXN gene, leading to reduced mitochondrial frataxin levels. Previously, we described a family displaying two expanded GAA alleles, not only in the proband affected by late-onset FRDA but also in the younger asymptomatic sister.
View Article and Find Full Text PDFEvaluating the Value of Eye-Tracking Augmented Debriefing in Medical Simulation-A Pilot Randomized Controlled Trial.
Simul Healthc
October 2024
From the Faculty of Health Sciences (H.B.), Office of Professional Development and Educational Scholarship; Faculty of Education, School of Medicine, Department of Biomedical and Molecular Sciences (H.B.), Queen's University, Kingston; Department of Emergency Medicine (A.K.H.), University of Ottawa, Ottawa; Royal College of Physicians and Surgeons of Canada (A.K.H.); Department of Emergency Medicine (K.C., D.D.), Queen's University; Departments of Emergency Medicine/Public Health Sciences (M.W.), Queen's University; Queen's Health Sciences (D.D.), Kingston; Department of Medicine (J.S.), McMaster Education Research, Innovation and Theory (MERIT) Program, McMaster University; Department of Medicine (M.S.), Centre for Simulation-Based Learning, McMaster University; Centre for Simulation-Based Learning (B.W.), McMaster University, Hamilton; Departments of Critical Care Medicine and Emergency Medicine (D.H.), Clinical Simulation Centre, Queen's University; Kingston General Hospital Research Institute (A.G.D.); Department of Family Medicine (W.W.), Queen's University; Departments of Emergency Medicine and Psychology (A.S.), Fellowship Program in Resuscitation and Reanimation; and Educational Scholarship Lead, Postgraduate Medical Education (A.S.), Queen's University, Kingston, ON, Canada.
Introduction: Debriefing after simulation facilitates reflective thinking and learning. Eye-tracking augmented debriefing (ETAD) may provide advantages over traditional debriefing (TD) by leveraging video replay with first-person perspective. This multisite randomized controlled trial compared the impact of ETAD with TD (without eye-tracking and without video) after simulation on 4 outcomes: (1) resident metacognitive awareness (the primary outcome), (2) cognitive load (CL) of residents and debriefers, (3) alignment of resident self-assessment and debriefer assessment scores, and (4) resident and debriefer perceptions of the debriefing experience.
View Article and Find Full Text PDFRoutine preoperative assessment for cataract surgery is a source of frustration for primary care providers.
BMC Health Serv Res
September 2024
Department of Anesthesia & Perioperative Care, University of California San Francisco, San Francisco, CA, USA.
Background: Cataract surgery is one of the most common surgical procedures performed in older adults in the United States and is generally considered to be extremely low-risk. As of 2019, routine preoperative evaluation within 30 days of surgery is no longer mandated by the United States of America (USA) Centers for Medicare & Medicaid Services (CMS) for ambulatory surgery centers, but it is unclear how primary care providers perceive this change.
Methods: We performed a qualitative analysis of semi-structured interviews with six primary care providers to explore primary care providers' perspectives on routine preoperative assessment for cataract surgery.
Team-, case-, lecture- and evidence-based learning in medical postgraduates training.
BMC Med Educ
June 2024
Department of Ophthalmology, The Second Xiangya Hospital of Central South University, 139 Renmin Middle Road, Changsha, 410011, China.
Background: The aim of this study was to evaluate the effectiveness of team-, case-, lecture-, and evidence-based learning (TCLEBL) methods in cultivating students' clinical and research abilities, as compared to traditional lecture-based learning (LBL) approaches.
Methods: Forty-one medical postgraduates were divided into two groups, a TCLEBL group and an LBL group. Teaching effectiveness was evaluated through student- and teacher-feedback questionnaires, scores from theoretical examinations and written literature reviews, and student learning burdens.
Perspectives on fatigue management among veterans living with multiple sclerosis.
Mult Scler Relat Disord
August 2024
Department of Rehabilitation Medicine, University of Washington School of Medicine, Box 359612, 325 9th Ave, Seattle, WA 98104, United States; Multiple Sclerosis Center of Excellence - West, Veterans Administration Puget Sound, Seattle Division, United States; Rehabilitation Care Service, VA Puget Sound Health Care System, Seattle, WA, United States.
Background: Chronic fatigue is one of the most common, disabling, and least understood symptoms of many chronic health conditions including multiple sclerosis (MS). A multidisciplinary rehabilitative treatment approach is recommended for MS-related fatigue, but few people with MS have access to such treatment. In-person and telehealth cognitive behavioral therapy (CBT) for fatigue is an emerging acceptable and effective treatment for MS-related fatigue in civilians that has not been studied in Veterans with MS, a population that is more likely to be older, male, unemployed, and disabled.
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