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Proteoglycan 4 (Lubricin) and regulation of xanthine oxidase in synovial macrophage as a mechanism of controlling synovitis.
Arthritis Res Ther
December 2024
Department of Emergency Medicine, Rhode Island Hospital, Providence, RI, USA.
Background: Synovial macrophages (SMs) are important effectors of joint health and disease. A novel Cx3CR1 + TREM2 + SM population expressing the tight junction protein claudin-5, was recently discovered in synovial lining. Ablation of these SMs was associated with onset of arthritis.
View Article and Find Full Text PDFComputational profiling and pharmacokinetic modelling of Febuxostat: Evaluating its potential as a therapeutic agent for diabetic wound healing.
Biochim Biophys Acta Gen Subj
January 2025
Department of Pharmacology, SRM College of Pharmacy, SRM Institute of Science and Technology, Kattankulathur, Chengalpattu 603203, Tamil Nadu, India. Electronic address:
Article Synopsis
- Diabetic wounds, common in Type 2 Diabetes, have slow healing due to impaired biological processes; the study investigates Febuxostat as a treatment option.
- Using various methodologies, including computational models and lab assays, researchers assessed Febuxostat's effects on wound healing pathways and its toxicity.
- Results showed Febuxostat has strong binding to key proteins involved in healing, demonstrated efficacy in promoting cell migration and closure in lab tests, and is deemed safe for use, warranting further clinical investigations.
Natural polysaccharides in the prevention of hyperuricemia: Source, classification, mechanism, application in food industry.
Int J Biol Macromol
December 2024
College of Food Science and Technology, Bohai University, National & Local Joint Engineering Research Center of Storage, Processing and Safety Control Technology for Fresh Agricultural and Aquatic Products, China Light Industry Key Laboratory of Marine Fish Processing, Jinzhou, Liaoning 121013, China.
Article Synopsis
- Hyperuricemia (HUA) is a growing health concern, prompting increased interest in both prevention and treatment options.
- Current medications like Allopurinol and Febuxostat are effective but can have significant side effects, leading to a search for safer, natural alternatives.
- Natural polysaccharides have shown promise in treating HUA, with research focusing on their sources, classifications, and their abilities to combat oxidative stress, inflammation, and lower uric acid levels.
Effects of catechins, resveratrol, silymarin components and some of their conjugates on xanthine oxidase-catalyzed xanthine and 6-mercaptopurine oxidation.
J Sci Food Agric
November 2024
Department of Laboratory Medicine, Medical School, University of Pécs, Pécs, Hungary.
Background: Over the past two decades, the global incidence of gout has markedly increased, affecting people worldwide. Considering the side effects of xanthine oxidase (XO) inhibitor drugs (e.g.
View Article and Find Full Text PDFFebuxostat-induced agranulocytosis in a pediatric hematopoietic stem cell transplant recipient: Case Report and literature review.
Front Pharmacol
October 2024
Department of Pediatrics, Institute for Maternal and Child Health IRCCS "Burlo Garofolo", Trieste, Italy.
This report describes a pediatric case of isolated agranulocytosis occurring months after hematopoietic stem cell transplantation (HSCT). Secondary cytopenia, or secondary transplant failure, affects 10%-25% of HSCT recipients, with potential triggers including viral infection, graft-versus-host disease (GVHD), sepsis, and certain medications. Viral reactivation was ruled out based on negative PCR results, while GVHD and sepsis were ruled out based on the patient's clinical presentation.
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