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Article Synopsis
- Abnormal uterine bleeding (AUB) is a prevalent issue in gynecology, with this study focusing on the relationship between endometrial glands and blood vessels in AUB patients.
- A retrospective analysis of 374 endometrial samples from women of reproductive age revealed significant differences in vascular density, diameter, mitotic activity, and glandular height among different benign and malignant conditions.
- The findings suggest that examining the structure of glands and blood vessels can help differentiate types of endometrial disorders, offering potential pathways for enhancing treatments through targeting angiogenesis.
Corticosteroids, androgens, progestogens and oestrogens in the endometrial microenvironment, and their association with endometrial progression and function.
Reprod Biomed Online
December 2024
IVIRMA Global Research Alliance, IVI Foundation, Instituto de Investigación Sanitaria La Fe (IIS La Fe), Valencia, Spain. Electronic address:
Research Question: How does the intracrine action of progestagens, oestrogens, androgens and corticosteroids affect endometrial tissue progression and function?
Design: In this prospective observational study, 76 patients (<50 years old, no uterine pathologies and at least one failed IVF cycle) undergoing endometrial biopsy collection for endometrial evaluation between 2018 and 2021 were included. The concentrations of 11 steroid metabolites (cortisone, cortisol, progesterone, oestrone, 2-methoxyestrone, oestradiol, oestriol, testosterone, androstenedione, 17α-hydroxyprogesterone and 17-hydroxypregnenolone) were measured by ultra-performance liquid chromatography-tandem mass spectrometry in the endometrial tissue samples collected during the mid-secretory phase. Endometrial dating and reproductive outcomes (relative to the next good-quality fresh or frozen embryo transfer after the biopsy) were analysed in relation to endometrial steroid concentrations using Barnard's test; correlations between metabolite concentrations were measured by Pearson's correlation co-efficient.
Uterine Sarcoma or Degenerating Fibroid? Validating the New Consensus Magnetic Resonance Imaging Algorithm for Evaluating Atypical Uterine Masses.
J Comput Assist Tomogr
October 2024
From the Department of Radiology, Northwestern Memorial Hospital, Northwestern University Feinberg School of Medicine, Chicago, IL.
Article Synopsis
- The study evaluated a new MRI diagnostic algorithm designed to distinguish between benign uterine leiomyomas and malignant uterine sarcomas in atypical cases.
- Researchers reviewed 40 cases of atypical uterine masses and found that the algorithm had strong accuracy metrics, with sensitivity and specificity rates around 75% and 95%, respectively.
- The results indicate that the consensus MRI algorithm is effective, achieving even higher accuracy when focusing on leiomyosarcomas, suggesting it could be a valuable tool for radiologists.
Effect of a novel copper chloride gel on endometrial growth and function in healthy volunteers.
Reprod Biomed Online
October 2024
School of Biosciences, University of Melbourne, Victoria, Australia.
Research Question: Does the application of a micro-dose of copper chloride gel increase endometrial production of vascular endothelial growth factor (VEGF) without compromising endometrial function or producing embryo toxicity?
Design: An estimate of optimal dose was made based on cell culture studies. Ten healthy participants received an initial uterine application of placebo gel, followed by copper chloride gel (37.5 μM, 75 μM, or 150 μM dose) in a later hormone replacement cycle.
Guideline No. 451: Asymptomatic Endometrial Thickening in Postmenopausal Women.
J Obstet Gynaecol Can
July 2024
Montréal, QC.
Objective: To formulate strategies for clinical assessments for endometrial thickening on ultrasound in a postmenopausal woman without bleeding.
Target Population: Postmenopausal women of any age.
Outcomes: To reduce unnecessary invasive interventions and investigations in women with asymptomatic endometrial thickening while selectively investigating women at risk for endometrial cancer.
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