Trivalent group-9 metal catalysts with a cyclopentadienyl-type ligand (CpM ; M=Co, Rh, Ir, Cp=cyclopentadienyl) have been widely used for directed C-H functionalizations, albeit that their application to challenging C(sp )-H functionalizations suffers from the limitations of the available directing groups. In this report, we describe directed C(sp )-H amidation reactions of simple amide substrates with a variety of substituents. The combination of an electron-deficient Cp Rh catalyst (Cp =1,3-bis(ethoxycarbonyl)-substituted Cp) and an electron-deficient 2-pyridone ligand is essential for high reactivity.
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| http://dx.doi.org/10.1002/anie.202213659 | DOI Listing |
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