[A 10-year retrospective study of pathogens and antimicrobial resistance in neonatal sepsis].

Objectives: To investigate the changes in the pathogen spectrum and antimicrobial resistance over time in neonatal sepsis.

Methods: The medical data were collected from the neonates who were diagnosed with sepsis in the Second Xiangya Hospital of Central South University from January 2010 to December 2019. The incidence rate of sepsis, the pathogen spectrum, and the characteristics of antimicrobial resistance were analyzed.

Results: The incidence rate of neonatal sepsis was 4.02% (447/11 111). The top four pathogens detected were coagulase-negative staphylococci (CoNS), , , and Candida. The incidence rate of sepsis and the pathogen spectrum showed no significant changes over time. was the most frequent pathogen in preterm infants, very low birth weight infants, and small-for-gestational-age infants, accounting for 33.9%, 29.5%, and 42.5%, respectively. CoNS, , and had a high resistance rate to penicillins and third-generation cephalosporins.

Conclusions: The incidence of neonatal sepsis is high, and the main pathogen is CoNS. The pathogens of neonatal sepsis have a high resistance rate to penicillins and third-generation cephalosporins. It is recommended to enhance the prevention and control of neonatal infection, strengthen the surveillance of pathogens, and further standardize the rational use of antibiotics.