Porcine respiratory diseases complex (PRDC) is a highly serious threat to the pig industry. In the present study, we investigated and analyzed the etiology associated with PRDC and explored the role of viruses in respiratory bacterial infections. From 2017 to 2021, clinical samples were collected from 1,307 pigs with typical respiratory symptoms in 269 farms in China and screened for pathogens related to PRDC by PCR and bacterial isolation. The results indicated that PRRSV (41.16%, 95%CI: 38.49~43.83%), PCV2 (21.58%,95%CI: 19.35~23.81%), (63.50%, 95%CI: 60.89~66.11%), and (28.54%, 95%CI: 26.09~30.99%) were the most commonly detected pathogens in pigs with PRDC in China. The dominant epidemic serotypes (serogroups) of , and were serotype 2, serotype 1, and capsular serogroups D, respectively. Pigs of different ages exhibited different susceptibilities to these pathogens, e.g., PRRSV, PCV2, and had the highest detection rates in nursery pigs, whereas fattening pigs had the highest detection rates of and . Among the 1,307 pigs, the detection rates of , and were higher in virus-positive pigs, especially and were significantly ( < 0.01) higher than in virus-negative pigs. In addition, a strong positive correlation was found between coinfection by PRRSV and (OR = 2.33, 95%CI: 1.12~2.14), PRRSV and (OR = 1.55, 95%CI: 1.12~2.14), PCV2 and (OR = 2.27, 95%CI: 1.33~3.87), PRRSV-PCV2 and (OR = 1.83, 95%CI: 1.29~2.60), PRRSV-PCV2 and (OR = 3.39, 95%CI: 2.42~4.74), and PRRSV-PCV2 and (OR = 2.09, 95%CI: 1.46~3.00). In summary, PRRSV, PCV2, , and were the major pathogens in pigs with PRDC, and coinfections of two or more PRDC-related pathogens with strong positive correlations were common in China, such as PRRSV and , PRRSV and , PCV2 and , and also PRRSV-PCV2 and and PRRSV-PCV2 and .

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9592729PMC
http://dx.doi.org/10.3389/fvets.2022.960033DOI Listing

Publication Analysis

Top Keywords

prrsv pcv2
12
detection rates
12
pigs
9
95%ci
9
etiology associated
8
porcine respiratory
8
2017 2021
8
1307 pigs
8
pathogens pigs
8
pigs prdc
8

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!