Until the month of April 2022, cases of monkeypox virus infection in humans were hardly documented outside of the endemic African regions. There are cases now throughout the world. Infected exotic pets have taken the monkeypox virus out of Africa. Following the universal eradication of smallpox in the 1970s, occurrences of monkeypox have attracted attention on a global scale. The western hemisphere and European nations are seeing the majority of the monkeypox infections linked to the 2022 epidemic. Numerous groups are working on contact-tracing initiatives, but it is still unclear what started this outbreak. The precise cause of monkeypox is uncertain, as the virus's origins have been linked to a number of rodents and small animals. Testing for monkeypox DNA from a patient using polymerase chain reaction (PCR) or viral culture isolation material can both be used to confirm monkeypox infection. Monkeypox is from the family: Poxviridae, subfamily: chordopoxvirinae, genus: orthopoxvirus and species: Monkeypox virus. The DNA virus monkeypox virus (MPXV), which causes the zoonotic illness MPX, or monkeypox, is divided into two genetic clades: The Congo Basin (CB) and the west Africa (WA) clades. Monkeypox's true impact on public health is uncertain.
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http://dx.doi.org/10.7759/cureus.29393 | DOI Listing |
Curr Drug Targets
January 2025
Department of Pharmacy, School of Medical and Allied Sciences, Galgotias University, Greater Noida, U.P., India.
MPOX is an orthopoxvirus whose infection has been declared a Public Health Emergency of International Concern in 2022 and 2024. It proved to be a virus with markedly heterogeneous and varied clinical presentation. We performed a systematic PubMed review of articles reporting cases of different clinical manifestations of MPOX until October 2024.
View Article and Find Full Text PDFFront Pharmacol
December 2024
Department of Microbiology, Dr. D. Y. Patil Medical College, Hospital and Research Centre, Dr. D. Y. Patil Vidyapeeth, Pune, Maharashtra, India.
Monkeypox, a zoonotic virus in the , has drawn global attention for its impact on public health. In the current Mpox outbreak, a novel clade, Ib, has emerged as a significant and potentially fatal threat. This review examines the dynamics of MPXV transmission, person-to-person spread, and infection mechanisms, highlighting key risk factors.
View Article and Find Full Text PDFPathog Glob Health
January 2025
Centro Estadual de Vigilância em Saúde, Secretaria de Saúde do Estado do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, do Sul, Brazil.
Mpox is a zoonotic viral disease caused by the (MPXV). Human cases have been mainly restricted to the African continent until the worldwide multi-country outbreak unfolded in 2022. We reconstructed epidemiological links of 53 MPXV infections using genomic epidemiology in Rio Grande do Sul State, southern Brazil, during 2022 and 2023.
View Article and Find Full Text PDFBioTech (Basel)
December 2024
State Research Center of Virology and Biotechnology VECTOR, Rospotrebnadzor, 630559 Koltsovo, Russia.
Heterologous protein expression often faces significant challenges, particularly when the target protein has posttranslational modifications, is toxic, or is prone to misfolding. These issues can result in low expression levels, aggregation, or even cell death. Such problems are exemplified by the expression of phospholipase p37, a critical target for chemotherapeutic drugs against pathogenic human orthopoxviruses, including monkeypox and smallpox viruses.
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