AI Article Synopsis
- Probiotics are microorganisms that promote health, especially by modulating immune responses and reducing inflammation.
- This study focused on nine strains of a specific probiotic bacteria, analyzing their genetic makeup to identify genes that contribute to their health benefits for humans.
- Key findings included shared genes linked to stress response, adhesion to human proteins, and the production of beneficial compounds, highlighting the potential of these strains to support gut health and overall wellness.
Article Abstract
Probiotics are health-beneficial microorganisms with mainly immunomodulatory and anti-inflammatory properties. species is a common bacteria used in the dairy industry, and their benefits to hosting health have been reported. This study analyzed the core genome of nine strains of species with documented probiotic properties, focusing on genes related to their host health benefits. For this, a combined methodology including several software and databases (BPGA, SPAAN, BAGEL4, BioCyc, KEEG, and InterSPPI) was used to predict the most important characteristics related to strains probiose. Comparative genomics analyses revealed that probiotic strains shared essential genes related to acid and bile stress response and antimicrobial activity. Other standard features shared by these strains are surface layer proteins and extracellular proteins-encoding genes, with high adhesion profiles that interacted with human proteins of the inflammatory signaling pathways (TLR2/4-MAPK, TLR2/4-NF-κB, and NOD-like receptors). Among these, the PrtB serine protease appears to be a strong candidate responsible for the anti-inflammatory properties reported for these strains. Furthermore, genes with high proteolytic and metabolic activity able to produce beneficial metabolites, such as acetate, bioactive peptides, and B-complex vitamins were also identified. These findings suggest that these proteins can be essential in biological mechanisms related to probiotics' beneficial effects of these strains in the host.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9580953 | PMC |
| http://dx.doi.org/10.3389/fbinf.2022.912795 | DOI Listing |
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