AI Article Synopsis
- Serial pancreatic juice aspiration cytological examination (SPACE) using liquid-based cytology (LBC) is an effective method for diagnosing early-stage pancreatic cancers that are hard to detect through traditional fine needle aspiration techniques.
- In a study of 24 patients, SPACE correctly identified 9 cases of malignancy with a high sensitivity of 81.8% and specificity of 100%, achieving an overall diagnostic accuracy of 91.7%.
- The procedure had a low complication rate and demonstrated adequate sample collection, making it a promising diagnostic tool for pancreatic cancer.
Article Abstract
Objectives: Serial pancreatic juice aspiration cytological examination (SPACE) via endoscopic retrograde cholangiopancreatography is a useful diagnostic method for early-stage pancreatic cancer, such as carcinoma in situ that are difficult to diagnose by endoscopic ultrasound-guided fine needle aspiration (EUS-FNA). However, the diagnostic accuracy of SPACE is low, which is attributed to problems regarding specimen treatment. Hence, we evaluated the diagnostic efficacy of liquid-based cytology (LBC) in pancreatic juice cytology for pancreatic cancer.
Methods: We retrospectively analyzed 24 patients with suspected pancreatic cancer that was difficult to diagnose by endoscopic ultrasound-guided fine needle aspiration who underwent SPACE using LBC between April 2017 and April 2021.
Results: The most common reason for performing SPACE was localized stenosis of the main pancreatic duct without a mass. Eleven patients were diagnosed with malignancy after surgical resection, nine of whom had pancreatic ductal adenocarcinoma. Ten patients were diagnosed as benign after a follow-up of more than 1 year. The nine cases of malignancy were diagnosed before surgical resection by SPACE using LBC, with a sensitivity of 81.8% and specificity of 100%. The overall diagnostic accuracy was 91.7%. A total of 152 LBC examinations were performed via SPACE, with an adequate sample collection rate of 88.9%. No adverse events, including acute pancreatitis, occurred after endoscopic retrograde cholangiopancreatography.
Conclusion: SPACE with LBC offers good diagnostic efficacy in patients with pancreatic cancer that is difficult to diagnose by endoscopic ultrasound-guided fine needle aspiration.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9593257 | PMC |
| http://dx.doi.org/10.1002/deo2.177 | DOI Listing |
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