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Myricetin prevents sleep deprivation-induced cognitive impairment and neuroinflammation in rat brain regulation of brain-derived neurotropic factor. | LitMetric

Myricetin prevents sleep deprivation-induced cognitive impairment and neuroinflammation in rat brain regulation of brain-derived neurotropic factor.

Korean J Physiol Pharmacol

Acupuncture and Meridian Science Research Center, Kyung Hee University, Seoul 02447, Korea.

Published: November 2022

AI Article Synopsis

Article Abstract

Memory formation in the hippocampus is formed and maintained by circadian clock genes during sleep. Sleep deprivation (SD) can lead to memory impairment and neuroinflammation, and there remains no effective pharmacological treatment for these effects. Myricetin (MYR) is a common natural flavonoid that has various pharmacological activities. In this study, we investigated the effects of MYR on memory impairment, neuroinflammation, and neurotrophic factors in sleep-deprived rats. We analyzed SD-induced cognitive and spatial memory, as well as pro-inflammatory cytokine levels during SD. SD model rats were intraperitoneally injected with 10 and 20 mg/kg/day MYR for 14 days. MYR administration significantly ameliorated SD-induced cognitive and spatial memory deficits; it also attenuated the SD-induced inflammatory response associated with nuclear factor kappa B activation in the hippocampus. In addition, MYR enhanced the mRNA expression of brain-derived neurotropic factor (BDNF) in the hippocampus. Our results showed that MYR improved memory impairment by means of anti-inflammatory activity and appropriate regulation of BDNF expression. Our findings suggest that MYR is a potential functional ingredient that protects cognitive function from SD.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9614391PMC
http://dx.doi.org/10.4196/kjpp.2022.26.6.415DOI Listing

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